Turnover ability of a designed RNA acting as a template for chemical peptide ligation

Kohei Yamashita, Norimasa Kashiwagi, Hiroyuki Furuta, Yoshiya Ikawa

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    A designed self-folding RNA possessing two peptiderecognition motifs served as a template for the chemical ligation of two RNA-binding peptides under stoichiometric conditions. In this study, we investigated theturnover ability of this template RNA in facilitation of peptide ligation and found that the RNA exhibited modest turnover ability under conditions in which its 3D structure was marginally stable.

    Original languageEnglish
    Pages (from-to)2021-2024
    Number of pages4
    JournalBioscience, Biotechnology and Biochemistry
    Volume75
    Issue number10
    DOIs
    Publication statusPublished - 2011

    All Science Journal Classification (ASJC) codes

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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