Turnover ability of a designed RNA acting as a template for chemical peptide ligation

Kohei Yamashita, Norimasa Kashiwagi, Hiroyuki Furuta, Yoshiya Ikawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A designed self-folding RNA possessing two peptiderecognition motifs served as a template for the chemical ligation of two RNA-binding peptides under stoichiometric conditions. In this study, we investigated theturnover ability of this template RNA in facilitation of peptide ligation and found that the RNA exhibited modest turnover ability under conditions in which its 3D structure was marginally stable.

Original languageEnglish
Pages (from-to)2021-2024
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number10
DOIs
Publication statusPublished - Oct 31 2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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