Two cases of histiocytic necrotizlng lymphadenitis (kikuchi-fujimoto’s disease) following diffuse large B-cell lymphoma

Tadashi Yoshino, Tomohiko Mannami, Koichi Ichimura, Katsuto Takenaka, Soichiro Nose, Ichiro Yamadori, Tadaatsu Akagi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Histiocytic necrotizing lymphadenitis (HNL) is often mistaken for malignant lymphoma clinically and is also sometimes difficult to differentiate from lymphoma even histopathologically. In this report, we describe the first 2 reported cases of HNL following non-Hodgkin’s lymphomas. The patients were 27- and 30-year-old women who developed cervical and axillary lymph node swellings, respectively, in the course of remission of diffuse large B-cell lymphoma. The affected lymph nodes showed the typical histology of HNL: irregular-shaped ’necrotic’ foci with histiocytes engulfing apoptotic bodies intermingled with large-sized blastic lymphocytes. These findings mimicked the partial involvement of large-cell lymphoma. However, the blastic cells were almost exclusively T cells, and numerous apoptotic bodies were present, which excluded the possibility of recurrence of diffuse large B-cell lymphoma. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)1328-1331
Number of pages4
JournalHuman Pathology
Volume31
Issue number10
DOIs
Publication statusPublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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