Abstract
We report two cases of invasive pancreatic cancer smaller than 30 mm in diameter which were suggested to be derived from small intraductal papillary mucinous neoplasm (IPMN). The patient in case 1 was a 67-year-old man, and a 17 mm branched IPMN was detected close to a pancreatic cancer. Pancreaticoduodenectomy was performed and the two tumors were histologically revealed to be adjacent to each other. Transitional features were also detected at the boundary. The patient in case 2 was a 59-year-old man, who had been followed for a 25 mm branched IPMN at the uncus of the pancreas for two years. The solitary pancreatic cancer close to this IPMN had been newly detected and pancreaticoduodenectomy was performed. Histologically, the cystic lesion contained components of IPMN and invasive adenocarcinoma. International consensus guidelines for the management of IPMN shows the indications for resection of branched duct IPMNs as those fitting the following 5 conditions, namely, larger than 30 mm in size, the presence of a mural nodule, cytologically positive pancreatic juice, dilatated main pancreatic duct, or symptomatic. However, similar to both of these two cases, invasive pancreatic cancer can be derived from small branched duct IPMN without any mural nodule. Careful attention is thus required to follow IPMNs.
| Original language | English |
|---|---|
| Pages (from-to) | 1202-1209 |
| Number of pages | 8 |
| Journal | Japanese Journal of Gastroenterological Surgery |
| Volume | 45 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 21 2012 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Gastroenterology
Cite this
Two cases of invasive pancreatic cancer suggesting derivation from small intraductal papillary mucinous neoplasms. / Kuroda, Yousuke; Nakashima, Yuichirou; Masuda, Takanobu; Maruyama, Seiji; Shimabukuro, Rinshun; Takahashi, Ikuo; Hida, Akira; Oshiro, Yumi; Nishizaki, Takashi.
In: Japanese Journal of Gastroenterological Surgery, Vol. 45, No. 12, 21.12.2012, p. 1202-1209.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Two cases of invasive pancreatic cancer suggesting derivation from small intraductal papillary mucinous neoplasms
AU - Kuroda, Yousuke
AU - Nakashima, Yuichirou
AU - Masuda, Takanobu
AU - Maruyama, Seiji
AU - Shimabukuro, Rinshun
AU - Takahashi, Ikuo
AU - Hida, Akira
AU - Oshiro, Yumi
AU - Nishizaki, Takashi
PY - 2012/12/21
Y1 - 2012/12/21
N2 - We report two cases of invasive pancreatic cancer smaller than 30 mm in diameter which were suggested to be derived from small intraductal papillary mucinous neoplasm (IPMN). The patient in case 1 was a 67-year-old man, and a 17 mm branched IPMN was detected close to a pancreatic cancer. Pancreaticoduodenectomy was performed and the two tumors were histologically revealed to be adjacent to each other. Transitional features were also detected at the boundary. The patient in case 2 was a 59-year-old man, who had been followed for a 25 mm branched IPMN at the uncus of the pancreas for two years. The solitary pancreatic cancer close to this IPMN had been newly detected and pancreaticoduodenectomy was performed. Histologically, the cystic lesion contained components of IPMN and invasive adenocarcinoma. International consensus guidelines for the management of IPMN shows the indications for resection of branched duct IPMNs as those fitting the following 5 conditions, namely, larger than 30 mm in size, the presence of a mural nodule, cytologically positive pancreatic juice, dilatated main pancreatic duct, or symptomatic. However, similar to both of these two cases, invasive pancreatic cancer can be derived from small branched duct IPMN without any mural nodule. Careful attention is thus required to follow IPMNs.
AB - We report two cases of invasive pancreatic cancer smaller than 30 mm in diameter which were suggested to be derived from small intraductal papillary mucinous neoplasm (IPMN). The patient in case 1 was a 67-year-old man, and a 17 mm branched IPMN was detected close to a pancreatic cancer. Pancreaticoduodenectomy was performed and the two tumors were histologically revealed to be adjacent to each other. Transitional features were also detected at the boundary. The patient in case 2 was a 59-year-old man, who had been followed for a 25 mm branched IPMN at the uncus of the pancreas for two years. The solitary pancreatic cancer close to this IPMN had been newly detected and pancreaticoduodenectomy was performed. Histologically, the cystic lesion contained components of IPMN and invasive adenocarcinoma. International consensus guidelines for the management of IPMN shows the indications for resection of branched duct IPMNs as those fitting the following 5 conditions, namely, larger than 30 mm in size, the presence of a mural nodule, cytologically positive pancreatic juice, dilatated main pancreatic duct, or symptomatic. However, similar to both of these two cases, invasive pancreatic cancer can be derived from small branched duct IPMN without any mural nodule. Careful attention is thus required to follow IPMNs.
UR - http://www.scopus.com/inward/record.url?scp=84871239077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871239077&partnerID=8YFLogxK
U2 - 10.5833/jjgs.45.1202
DO - 10.5833/jjgs.45.1202
M3 - Article
AN - SCOPUS:84871239077
VL - 45
SP - 1202
EP - 1209
JO - Japanese Journal of Gastroenterological Surgery
JF - Japanese Journal of Gastroenterological Surgery
SN - 0386-9768
IS - 12
ER -