Two cases of Kaposi sarcoma

Kazuko Doi, Hiroshi Ureshino, Masaharu Miyahara, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

Case 1 :A 45-year-old Japanese man, who was diagnosed with acquired immunodeficiency syndrome (AIDS) with pneumocystis pneumonia, presented multiple violaceous plaques and nodules on his face, neck, and toes. Case 2 :An 84-yearold Japanese man without HIV infection developed a violaceous nodule on his dorsal foot after extensive chemotherapy for diffuse large B cell lymphoma. The lesion slowly became enlarged. Skin biopsies of both cases revealed a proliferation of spindle cells forming vascular slits in the dermis. Immunohistochemically, the tumor cells were positive for CD31, CD34, D2- 40, and LANA-1. We therefore diagnosed case 1 as AIDS-associated Kaposi sarcoma (KS) and case 2 as iatrogenic KS. Although its etiology remains unclear, KS is supposed to be a kind of opportunistic tumor occurring due to HHV-8 infection following severe immunosuppression caused by aging, drugs, and/or other viruses. We encountered four cases of AIDSassociated KS and one of iatrogenic KS in three years (2012-2014). We must be aware that KS can occur in individuals receiving immunosuppressive therapy.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalNishinihon Journal of Dermatology
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Kaposi's Sarcoma
Acquired Immunodeficiency Syndrome
Human Herpesvirus 8
Pneumocystis Pneumonia
Lymphoma, Large B-Cell, Diffuse
Toes
Immunosuppressive Agents
Dermis
Immunosuppression
HIV Infections
Blood Vessels
Foot
Neoplasms
Neck
Cell Proliferation
Viruses
Biopsy
Drug Therapy
Skin
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology

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Two cases of Kaposi sarcoma. / Doi, Kazuko; Ureshino, Hiroshi; Miyahara, Masaharu; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 78, No. 1, 01.01.2016, p. 44-49.

Research output: Contribution to journalArticle

Doi, Kazuko ; Ureshino, Hiroshi ; Miyahara, Masaharu ; Furue, Masutaka. / Two cases of Kaposi sarcoma. In: Nishinihon Journal of Dermatology. 2016 ; Vol. 78, No. 1. pp. 44-49.
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