Two cases of pulmonary cryptococcosis, negative of serum cryptococcal antigen and difficult to differentiate lung cancer

Satoshi Ikegame, Ichiro Inoshima, Hiroshi Ouchi, Eiji Harada, Masaki Fujita, Yoichi Nakanishi

Research output: Contribution to journalArticle

Abstract

Background. Pulmonary cryptococcosis sometimes presents as a solitary pulmonary nodule, therefore problems in distinguishing lung cancer and cryptococcosis often arises. The usefulness of serum cryptococcal antigen for the diagnosis of pulmonary cryptococcosis has been emphasized. However there are not a few cases negative for serum antigen when pulmonary cryptococcosis appeared as a solitary lung nodule. Recently we encountered 2 cases of serum antigen-negative pulmonary cryptococcosis. Cases. Case 1 was found on a chest radiograph in an annual medical checkup and case 2 complained of low grade fever. Solitary pulmonary nodules were pointed out in both cases. Chest CT revealed spiculation of these nodules, but no daughter lesion. Therefore these nodules were strongly suspected to be lung cancer. Case 1 was diagnosed as cryptococcosis by fiber-optic bronchoscopy, case 2 was diagnosed by lung biopsy via thoracoscopy, and both cases were successfully treated by fluconazole. Conclusion. Serum cryptococcal antigen may not be detected in cases of pulmonary cryptococcosis presenting as a solitary lung nodule, therefore the development of more effective examinations is required.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalJapanese Journal of Lung Cancer
Volume47
Issue number3
DOIs
Publication statusPublished - Jun 1 2007

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Cryptococcosis
Lung Neoplasms
Antigens
Lung
Serum
Solitary Pulmonary Nodule
Thorax
Thoracoscopy
Fluconazole
Bronchoscopy
Fever
Biopsy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Two cases of pulmonary cryptococcosis, negative of serum cryptococcal antigen and difficult to differentiate lung cancer. / Ikegame, Satoshi; Inoshima, Ichiro; Ouchi, Hiroshi; Harada, Eiji; Fujita, Masaki; Nakanishi, Yoichi.

In: Japanese Journal of Lung Cancer, Vol. 47, No. 3, 01.06.2007, p. 251-255.

Research output: Contribution to journalArticle

Ikegame, Satoshi ; Inoshima, Ichiro ; Ouchi, Hiroshi ; Harada, Eiji ; Fujita, Masaki ; Nakanishi, Yoichi. / Two cases of pulmonary cryptococcosis, negative of serum cryptococcal antigen and difficult to differentiate lung cancer. In: Japanese Journal of Lung Cancer. 2007 ; Vol. 47, No. 3. pp. 251-255.
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