Two-component signal transduction as potential drug targets in pathogenic bacteria

Yasuhiro Gotoh, Yoko Eguchi, Takafumi Watanabe, Sho Okamoto, Akihiro Doi, Ryutaro Utsumi

Research output: Contribution to journalReview articlepeer-review

178 Citations (Scopus)

Abstract

Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective against various drug-resistant bacteria may be possible. Furthermore, inhibitors of TCSs that control virulence factors may reduce virulence without killing the pathogenic bacteria. Previous TCS inhibitors targeting the kinase domain of the histidine kinase sensor suffered from poor selectivity. Recent TCS inhibitors, however, target the sensory domains of the sensors blocking the quorum sensing system, or target the essential response regulator. These new targets are introduced, together with several specific TCSs that have the potential to serve as effective drug targets.

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalCurrent Opinion in Microbiology
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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