Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain

E. F.L. Chiang, Y. L. Yan, Y. Guiguen, J. Postlethwait, B. C. Chung

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Cytochrome P450 aromatase (Cyp19) is an enzyme catalyzing the synthesis of estrogens, thereby controlling various physiological functions of estrogens. We isolated two cyp19 cDNAs, termed cyp19a and cyp19b, respectively, from zebrafish. These genes are located in linkage groups 18 and 25, respectively. Detailed gene mapping indicated that zebrafish linkage groups 18 and 25 may have arisen from the same ancestral chromosome by a chromosome duplication event. Cyp19a is expressed mainly in the follicular cells lining the vitellogenic oocytes in the ovary during vitellogenesis. Cyp19b is expressed abundantly in the brain, at the hypothalamus and ventral telencephalon, extending to the olfactory bulbs. The expression of duplicated cyp19 genes at two different tissues highlights the evolutionary significance of maintaining two active genes on duplicated zebrafish chromosomes for specific functions in the ovary and the brain.

Original languageEnglish
Pages (from-to)542-550
Number of pages9
JournalMolecular Biology and Evolution
Volume18
Issue number4
DOIs
Publication statusPublished - Jan 1 2001

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Aromatase
Zebrafish
Danio rerio
brain
chromosome
Ovary
Chromosomes
chromosomes
linkage groups
estrogens
gene
Brain
Estrogens
Chromosome Duplication
Vitellogenesis
Genes
Telencephalon
olfactory bulb
genes
Chromosome Mapping

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. / Chiang, E. F.L.; Yan, Y. L.; Guiguen, Y.; Postlethwait, J.; Chung, B. C.

In: Molecular Biology and Evolution, Vol. 18, No. 4, 01.01.2001, p. 542-550.

Research output: Contribution to journalArticle

Chiang, E. F.L. ; Yan, Y. L. ; Guiguen, Y. ; Postlethwait, J. ; Chung, B. C. / Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. In: Molecular Biology and Evolution. 2001 ; Vol. 18, No. 4. pp. 542-550.
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