Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata

Toshiyuki Hamada, Kazushi Kobayashi, Naomichi Arima, Fumito Tani, Charles Santhanaraju Vairappan, Satoaki Onitsuka, Hiroaki Okamura

Research output: Contribution to journalArticle

Abstract

The red alga Chondria armata is known to produce and contain a rich diversity of secondary metabolites, such as domoic acid-related alkaloids and triterpene polyethers. Our investigation on red alga C. armata from Kagoshima coast, Japan, resulted in the isolation of two new triterpene polyethers, bandokorols A (1) and B (2). The structures of these compounds were determined based on spectroscopic data such as infrared (FTIR), 1H-NMR, APT, 1H–1H-COSY, HSQC, HMBC, NOESY and FAB mass spectrometry (HRFABMS). The anticancer potentials of these compounds were tested against adult T-cell leukaemia (ATL), S1T cells and their IC50 values are reported here.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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    Hamada, T., Kobayashi, K., Arima, N., Tani, F., Vairappan, C. S., Onitsuka, S., & Okamura, H. (Accepted/In press). Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata. Natural Product Research. https://doi.org/10.1080/14786419.2020.1777411