TY - JOUR
T1 - Two-Dimensional Cellular Patterning on a Polymer Film Based on Interfacial Stiffness
AU - Kawabata, Kento
AU - Totani, Masayasu
AU - Kawaguchi, Daisuke
AU - Matsuno, Hisao
AU - Tanaka, Keiji
N1 - Funding Information:
This study was partially supported by JSPS KAKENHI Grant-in-Aids for Scientific Research (B) JP20H02790 (K.T.) and (B) JP18H02037 (H.M.) and for Early-Career Scientists (JP21K14684, M.T.). The authors are grateful for support from the JST-Mirai Program (JPMJMI18A2, K.T.).
Publisher Copyright:
© 2021 American Chemical Society
PY - 2021/12/28
Y1 - 2021/12/28
N2 - The mechanical properties in the outermost region of a polymer film strongly affect various material functions. We here propose a novel and promising strategy for the two-dimensional regulation of the mechanical properties of a polymer film at the water interface based on an inkjet drawing of silica nanoparticles (SNPs) underneath it. A film of poly(2-hydroxyethyl methacrylate) (PHEMA), which exhibits excellent bioinertness properties at the water interface, was well fabricated on a substrate with a pattern of SNPs. X-ray photoelectron spectroscopy and atomic force microscopy confirmed that the surface of the PHEMA film was flat and chemically homogeneous. However, the film surface was in-plane heterogeneous in stiffness due to the presence of the underlying SNP lines. It was also noted that NIH/3T3 fibroblast cells selectively adhered and formed aggregates on the areas under which an SNP line was drawn.
AB - The mechanical properties in the outermost region of a polymer film strongly affect various material functions. We here propose a novel and promising strategy for the two-dimensional regulation of the mechanical properties of a polymer film at the water interface based on an inkjet drawing of silica nanoparticles (SNPs) underneath it. A film of poly(2-hydroxyethyl methacrylate) (PHEMA), which exhibits excellent bioinertness properties at the water interface, was well fabricated on a substrate with a pattern of SNPs. X-ray photoelectron spectroscopy and atomic force microscopy confirmed that the surface of the PHEMA film was flat and chemically homogeneous. However, the film surface was in-plane heterogeneous in stiffness due to the presence of the underlying SNP lines. It was also noted that NIH/3T3 fibroblast cells selectively adhered and formed aggregates on the areas under which an SNP line was drawn.
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U2 - 10.1021/acs.langmuir.1c02776
DO - 10.1021/acs.langmuir.1c02776
M3 - Article
AN - SCOPUS:85121700058
VL - 37
SP - 14911
EP - 14919
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 51
ER -