Two-generation reproductive toxicity study of tributyltin chloride in female rats

Rika Ogata, Minoru Omura, Yohei Shimasaki, Kazuhiko Kubo, Yuji Oshima, Aou Shuji, Naohide Inoue

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCI) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCI. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCI group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCI group. However, an increase in anogenital distance was found in all TBTCI groups on postnatal d 1. A dose-effect relationship was observed in TBTCI-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCI affects the sexual development and reproductive function of female rats. In addition, the TBTCI-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCI used in this study are not environmentally relevant.

Original languageEnglish
Pages (from-to)127-144
Number of pages18
JournalJournal of Toxicology and Environmental Health - Part A
Volume63
Issue number2
DOIs
Publication statusPublished - May 25 2001

Fingerprint

Toxicity
Rats
Body Weight
tributyltin
Sexual Development
Periodicity
Dams
Weight Gain
Growth

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Two-generation reproductive toxicity study of tributyltin chloride in female rats. / Ogata, Rika; Omura, Minoru; Shimasaki, Yohei; Kubo, Kazuhiko; Oshima, Yuji; Shuji, Aou; Inoue, Naohide.

In: Journal of Toxicology and Environmental Health - Part A, Vol. 63, No. 2, 25.05.2001, p. 127-144.

Research output: Contribution to journalArticle

Ogata, Rika ; Omura, Minoru ; Shimasaki, Yohei ; Kubo, Kazuhiko ; Oshima, Yuji ; Shuji, Aou ; Inoue, Naohide. / Two-generation reproductive toxicity study of tributyltin chloride in female rats. In: Journal of Toxicology and Environmental Health - Part A. 2001 ; Vol. 63, No. 2. pp. 127-144.
@article{dad5f28b526249f09d26cf594ddf5531,
title = "Two-generation reproductive toxicity study of tributyltin chloride in female rats",
abstract = "A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCI) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCI. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCI group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCI group. However, an increase in anogenital distance was found in all TBTCI groups on postnatal d 1. A dose-effect relationship was observed in TBTCI-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCI affects the sexual development and reproductive function of female rats. In addition, the TBTCI-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCI used in this study are not environmentally relevant.",
author = "Rika Ogata and Minoru Omura and Yohei Shimasaki and Kazuhiko Kubo and Yuji Oshima and Aou Shuji and Naohide Inoue",
year = "2001",
month = "5",
day = "25",
doi = "10.1080/15287390151126469",
language = "English",
volume = "63",
pages = "127--144",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "1528-7394",
publisher = "Taylor and Francis Ltd.",
number = "2",

}

TY - JOUR

T1 - Two-generation reproductive toxicity study of tributyltin chloride in female rats

AU - Ogata, Rika

AU - Omura, Minoru

AU - Shimasaki, Yohei

AU - Kubo, Kazuhiko

AU - Oshima, Yuji

AU - Shuji, Aou

AU - Inoue, Naohide

PY - 2001/5/25

Y1 - 2001/5/25

N2 - A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCI) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCI. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCI group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCI group. However, an increase in anogenital distance was found in all TBTCI groups on postnatal d 1. A dose-effect relationship was observed in TBTCI-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCI affects the sexual development and reproductive function of female rats. In addition, the TBTCI-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCI used in this study are not environmentally relevant.

AB - A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCI) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCI. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCI group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCI group. However, an increase in anogenital distance was found in all TBTCI groups on postnatal d 1. A dose-effect relationship was observed in TBTCI-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCI affects the sexual development and reproductive function of female rats. In addition, the TBTCI-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCI used in this study are not environmentally relevant.

UR - http://www.scopus.com/inward/record.url?scp=0035947485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035947485&partnerID=8YFLogxK

U2 - 10.1080/15287390151126469

DO - 10.1080/15287390151126469

M3 - Article

C2 - 11393799

AN - SCOPUS:0035947485

VL - 63

SP - 127

EP - 144

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 1528-7394

IS - 2

ER -