TY - JOUR
T1 - Two-generation reproductive toxicity study of tributyltin chloride in female rats
AU - Ogata, Rika
AU - Omura, Minoru
AU - Shimasaki, Yohei
AU - Kubo, Kazuhiko
AU - Oshima, Yuji
AU - Shuji, Aou
AU - Inoue, Naohide
N1 - Funding Information:
Received 28 July 2000; sent for revision 30 August and 28 September 2000; accepted 13 October 2000. We thank Yoshiko Hirose for her technical assistance. This study was supported by grant 11839017 from the Ministry of Education, Science and Culture, Japan. Address correspondence to Rika Ogata, Department of Hygiene, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. E-mail: rogata@eisei.med.kyushu-u.ac.jp
PY - 2001/5/25
Y1 - 2001/5/25
N2 - A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCI) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCI. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCI group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCI group. However, an increase in anogenital distance was found in all TBTCI groups on postnatal d 1. A dose-effect relationship was observed in TBTCI-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCI affects the sexual development and reproductive function of female rats. In addition, the TBTCI-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCI used in this study are not environmentally relevant.
AB - A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCI) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCI. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCI group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCI group. However, an increase in anogenital distance was found in all TBTCI groups on postnatal d 1. A dose-effect relationship was observed in TBTCI-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCI affects the sexual development and reproductive function of female rats. In addition, the TBTCI-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCI used in this study are not environmentally relevant.
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U2 - 10.1080/15287390151126469
DO - 10.1080/15287390151126469
M3 - Article
C2 - 11393799
AN - SCOPUS:0035947485
SN - 1528-7394
VL - 63
SP - 127
EP - 144
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 2
ER -