Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease

Hisamitsu Uno, Takehiko Sasazuki, Hajime Tamai, Hideo Matsumoto

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Graves' disease is a multifactorial disease in which immunogenetic as well as environmental factors have important roles. Recently, cumulative evidence has shown that genes controlling immune responses are linked to the MHC (major histocompatibility complex)1 and/or immunoglobulin allotype genes2,3. To identify the genes governing susceptibility to Graves' disease, we have studied 30 Japanese families where more than two first degree relatives were affected with the disease. From genetic analysis of HLA (human MHC) and immunoglobulin allotype of all family members, we present here evidence for the existence of two genes controlling the susceptibility to Graves' disease, one closely linked to HLA-DR, the other linked to the gene coding for the Gm allotype.

Original languageEnglish
Pages (from-to)768-770
Number of pages3
JournalNature
Volume292
Issue number5825
DOIs
Publication statusPublished - Dec 1 1981
Externally publishedYes

Fingerprint

Graves Disease
Immunoglobulin Allotypes
Major Histocompatibility Complex
Genes
Immunoglobulin Gm Allotypes
Immunogenetics
HLA-DR Antigens

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • General

Cite this

Uno, H., Sasazuki, T., Tamai, H., & Matsumoto, H. (1981). Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease. Nature, 292(5825), 768-770. https://doi.org/10.1038/292768a0

Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease. / Uno, Hisamitsu; Sasazuki, Takehiko; Tamai, Hajime; Matsumoto, Hideo.

In: Nature, Vol. 292, No. 5825, 01.12.1981, p. 768-770.

Research output: Contribution to journalArticle

Uno, H, Sasazuki, T, Tamai, H & Matsumoto, H 1981, 'Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease', Nature, vol. 292, no. 5825, pp. 768-770. https://doi.org/10.1038/292768a0
Uno, Hisamitsu ; Sasazuki, Takehiko ; Tamai, Hajime ; Matsumoto, Hideo. / Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease. In: Nature. 1981 ; Vol. 292, No. 5825. pp. 768-770.
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