Two novel triterpenoid saponins (1 and 2) have been isolated from the roots of Acanthophyllum squarrosum. The structures were established mainly by a combination of 2D NMR techniques as 3-O-β-D-galactopyranosyl-(1→2)[β-D-xylopyranosyl-(1→3)-β-D-glucuronopyra nosylgypsogenin-28-O-β-D-xylopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L -rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→3)]-β-D-fucopyranoside (1) and 3-O-β-D-glucopyranosylgypsogenin-28-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabi nopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside (2). Compound 1 showed a moderate concentration-dependent immunomodulatory effect in an in vitro lymphocyte proliferation assay.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry