Two new biologically active triterpene saponins from Acanthophyllum squarrosum

Ghezala Gaidi, Tomofumi Miyamoto, Abdolhossein Rustaiyan, Véronique Laurens, Marie Aleth Lacaille-Dubois

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Abstract

Two novel triterpenoid saponins (1 and 2) have been isolated from the roots of Acanthophyllum squarrosum. The structures were established mainly by a combination of 2D NMR techniques as 3-O-β-D-galactopyranosyl-(1→2)[β-D-xylopyranosyl-(1→3)-β-D-glucuronopyra nosylgypsogenin-28-O-β-D-xylopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L -rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→3)]-β-D-fucopyranoside (1) and 3-O-β-D-glucopyranosylgypsogenin-28-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabi nopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside (2). Compound 1 showed a moderate concentration-dependent immunomodulatory effect in an in vitro lymphocyte proliferation assay.

Original languageEnglish
Pages (from-to)1497-1502
Number of pages6
JournalJournal of Natural Products
Volume63
Issue number11
DOIs
Publication statusPublished - Dec 10 2000

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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