TY - JOUR
T1 - Two-step selection criteria for living donor liver transplantation in patients with hepatocellular carcinoma
AU - Yoshizumi, T.
AU - Ikegami, T.
AU - Toshima, T.
AU - Harimoto, N.
AU - Uchiyama, H.
AU - Soejima, Y.
AU - Yamashita, Y.
AU - Shirabe, K.
AU - Maehara, Y.
N1 - Funding Information:
This study was partly funded by a grant-in-aid (Grant 23591989 ) from the Ministry of Education, Science, and Culture in Japan .
PY - 2013/11
Y1 - 2013/11
N2 - We have proposed risk factors for tumor recurrence, such as tumor nodule ≥5 cm and des-gamma-carboxy prothrombin ≥300 mAU/mL after living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). The aim of this study was to clarify the risk factors for HCC recurrence and mortality within our criteria. We enrolled 152 adult recipients who had undergone LDLT for end-stage liver disease with HCC who met our criteria. The recurrence-free survival rates after LDLT were calculated. Risk factors for tumor recurrence were identified. On univariate analysis, factors affecting recurrence-free survival were pretransplant treatment for HCC, neutrophil-to-lumphocyte ratio (NLR) >4, alpha-fetoprotein ≥400 ng/mL, ≥5 nodules, and bilobar tumor distribution. Multivariate analysis identified that NLR >4 and ≥5 nodules were independent risk factors for tumor recurrence after LDLT (P =.003 and P =.002, respectively). Two-step selection criteria enable selection of patients who have high-risk of tumor recurrence.
AB - We have proposed risk factors for tumor recurrence, such as tumor nodule ≥5 cm and des-gamma-carboxy prothrombin ≥300 mAU/mL after living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). The aim of this study was to clarify the risk factors for HCC recurrence and mortality within our criteria. We enrolled 152 adult recipients who had undergone LDLT for end-stage liver disease with HCC who met our criteria. The recurrence-free survival rates after LDLT were calculated. Risk factors for tumor recurrence were identified. On univariate analysis, factors affecting recurrence-free survival were pretransplant treatment for HCC, neutrophil-to-lumphocyte ratio (NLR) >4, alpha-fetoprotein ≥400 ng/mL, ≥5 nodules, and bilobar tumor distribution. Multivariate analysis identified that NLR >4 and ≥5 nodules were independent risk factors for tumor recurrence after LDLT (P =.003 and P =.002, respectively). Two-step selection criteria enable selection of patients who have high-risk of tumor recurrence.
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U2 - 10.1016/j.transproceed.2013.05.001
DO - 10.1016/j.transproceed.2013.05.001
M3 - Article
C2 - 24182807
AN - SCOPUS:84887101962
VL - 45
SP - 3310
EP - 3313
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 9
ER -