Two-step selection criteria for living donor liver transplantation in patients with hepatocellular carcinoma

T. Yoshizumi, T. Ikegami, T. Toshima, N. Harimoto, H. Uchiyama, Y. Soejima, Y. Yamashita, K. Shirabe, Y. Maehara

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Abstract

We have proposed risk factors for tumor recurrence, such as tumor nodule ≥5 cm and des-gamma-carboxy prothrombin ≥300 mAU/mL after living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). The aim of this study was to clarify the risk factors for HCC recurrence and mortality within our criteria. We enrolled 152 adult recipients who had undergone LDLT for end-stage liver disease with HCC who met our criteria. The recurrence-free survival rates after LDLT were calculated. Risk factors for tumor recurrence were identified. On univariate analysis, factors affecting recurrence-free survival were pretransplant treatment for HCC, neutrophil-to-lumphocyte ratio (NLR) >4, alpha-fetoprotein ≥400 ng/mL, ≥5 nodules, and bilobar tumor distribution. Multivariate analysis identified that NLR >4 and ≥5 nodules were independent risk factors for tumor recurrence after LDLT (P =.003 and P =.002, respectively). Two-step selection criteria enable selection of patients who have high-risk of tumor recurrence.

Original languageEnglish
Pages (from-to)3310-3313
Number of pages4
JournalTransplantation Proceedings
Volume45
Issue number9
DOIs
Publication statusPublished - Nov 1 2013

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Living Donors
Liver Transplantation
Patient Selection
Hepatocellular Carcinoma
Recurrence
Neoplasms
Neutrophils
End Stage Liver Disease
alpha-Fetoproteins
Multivariate Analysis
Survival Rate
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Two-step selection criteria for living donor liver transplantation in patients with hepatocellular carcinoma. / Yoshizumi, T.; Ikegami, T.; Toshima, T.; Harimoto, N.; Uchiyama, H.; Soejima, Y.; Yamashita, Y.; Shirabe, K.; Maehara, Y.

In: Transplantation Proceedings, Vol. 45, No. 9, 01.11.2013, p. 3310-3313.

Research output: Contribution to journalArticle

Yoshizumi, T. ; Ikegami, T. ; Toshima, T. ; Harimoto, N. ; Uchiyama, H. ; Soejima, Y. ; Yamashita, Y. ; Shirabe, K. ; Maehara, Y. / Two-step selection criteria for living donor liver transplantation in patients with hepatocellular carcinoma. In: Transplantation Proceedings. 2013 ; Vol. 45, No. 9. pp. 3310-3313.
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AU - Soejima, Y.

AU - Yamashita, Y.

AU - Shirabe, K.

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