Type 2diabetes as a risk factor for dementia in women compared with men: A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia

Saion Chatterjee, Sanne A.E. Peters, Mark Woodward, Silvia Mejia Arango, G. David Batty, Nigel Beckett, Alexa Beiser, Amy R. Borenstein, Paul K. Crane, Mary Haan, Linda B. Hassing, Kathleen M. Hayden, Yutaka Kiyohara, Eric B. Larson, Chung Yi Li, Toshiharu Ninomiya, Tomoyuki Ohara, Ruth Peters, Tom C. Russ, Sudha SeshadriBjørn H. Strand, Rod Walker, Weili Xu, Rachel R. Huxley

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Abstract

Objective Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a metaanalysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. Research Design and Methods A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. Results Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45-1.80]; men: pooled RR 1.58 [95% CI 1.38-1.81]). The diabetesassociated RRs for vascular dementia were 2.34 (95% CI 1.86-2.94) in women and 1.73 (95% CI 1.61-1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35-1.73) in women and 1.49 (95% CI 1.31-1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08-1.30]; P <0.001). Conclusions Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.

Original languageEnglish
Pages (from-to)300-307
Number of pages8
JournalDiabetes care
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2016

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Dementia
Vascular Dementia
Type 2 Diabetes Mellitus
Meta-Analysis
Research Design
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Type 2diabetes as a risk factor for dementia in women compared with men : A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. / Chatterjee, Saion; Peters, Sanne A.E.; Woodward, Mark; Arango, Silvia Mejia; Batty, G. David; Beckett, Nigel; Beiser, Alexa; Borenstein, Amy R.; Crane, Paul K.; Haan, Mary; Hassing, Linda B.; Hayden, Kathleen M.; Kiyohara, Yutaka; Larson, Eric B.; Li, Chung Yi; Ninomiya, Toshiharu; Ohara, Tomoyuki; Peters, Ruth; Russ, Tom C.; Seshadri, Sudha; Strand, Bjørn H.; Walker, Rod; Xu, Weili; Huxley, Rachel R.

In: Diabetes care, Vol. 39, No. 2, 02.2016, p. 300-307.

Research output: Contribution to journalArticle

Chatterjee, S, Peters, SAE, Woodward, M, Arango, SM, Batty, GD, Beckett, N, Beiser, A, Borenstein, AR, Crane, PK, Haan, M, Hassing, LB, Hayden, KM, Kiyohara, Y, Larson, EB, Li, CY, Ninomiya, T, Ohara, T, Peters, R, Russ, TC, Seshadri, S, Strand, BH, Walker, R, Xu, W & Huxley, RR 2016, 'Type 2diabetes as a risk factor for dementia in women compared with men: A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia', Diabetes care, vol. 39, no. 2, pp. 300-307. https://doi.org/10.2337/dc15-1588
Chatterjee, Saion ; Peters, Sanne A.E. ; Woodward, Mark ; Arango, Silvia Mejia ; Batty, G. David ; Beckett, Nigel ; Beiser, Alexa ; Borenstein, Amy R. ; Crane, Paul K. ; Haan, Mary ; Hassing, Linda B. ; Hayden, Kathleen M. ; Kiyohara, Yutaka ; Larson, Eric B. ; Li, Chung Yi ; Ninomiya, Toshiharu ; Ohara, Tomoyuki ; Peters, Ruth ; Russ, Tom C. ; Seshadri, Sudha ; Strand, Bjørn H. ; Walker, Rod ; Xu, Weili ; Huxley, Rachel R. / Type 2diabetes as a risk factor for dementia in women compared with men : A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. In: Diabetes care. 2016 ; Vol. 39, No. 2. pp. 300-307.
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title = "Type 2diabetes as a risk factor for dementia in women compared with men: A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia",
abstract = "Objective Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a metaanalysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. Research Design and Methods A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95{\%} CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. Results Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60{\%} increased risk of any dementia in both sexes (women: pooled RR 1.62 [95{\%} CI 1.45-1.80]; men: pooled RR 1.58 [95{\%} CI 1.38-1.81]). The diabetesassociated RRs for vascular dementia were 2.34 (95{\%} CI 1.86-2.94) in women and 1.73 (95{\%} CI 1.61-1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95{\%} CI 1.35-1.73) in women and 1.49 (95{\%} CI 1.31-1.69) in men. Overall, women with diabetes had a 19{\%} greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95{\%} CI 1.08-1.30]; P <0.001). Conclusions Individuals with type 2 diabetes are at ∼60{\%} greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.",
author = "Saion Chatterjee and Peters, {Sanne A.E.} and Mark Woodward and Arango, {Silvia Mejia} and Batty, {G. David} and Nigel Beckett and Alexa Beiser and Borenstein, {Amy R.} and Crane, {Paul K.} and Mary Haan and Hassing, {Linda B.} and Hayden, {Kathleen M.} and Yutaka Kiyohara and Larson, {Eric B.} and Li, {Chung Yi} and Toshiharu Ninomiya and Tomoyuki Ohara and Ruth Peters and Russ, {Tom C.} and Sudha Seshadri and Strand, {Bj{\o}rn H.} and Rod Walker and Weili Xu and Huxley, {Rachel R.}",
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T1 - Type 2diabetes as a risk factor for dementia in women compared with men

T2 - A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia

AU - Chatterjee, Saion

AU - Peters, Sanne A.E.

AU - Woodward, Mark

AU - Arango, Silvia Mejia

AU - Batty, G. David

AU - Beckett, Nigel

AU - Beiser, Alexa

AU - Borenstein, Amy R.

AU - Crane, Paul K.

AU - Haan, Mary

AU - Hassing, Linda B.

AU - Hayden, Kathleen M.

AU - Kiyohara, Yutaka

AU - Larson, Eric B.

AU - Li, Chung Yi

AU - Ninomiya, Toshiharu

AU - Ohara, Tomoyuki

AU - Peters, Ruth

AU - Russ, Tom C.

AU - Seshadri, Sudha

AU - Strand, Bjørn H.

AU - Walker, Rod

AU - Xu, Weili

AU - Huxley, Rachel R.

PY - 2016/2

Y1 - 2016/2

N2 - Objective Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a metaanalysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. Research Design and Methods A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. Results Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45-1.80]; men: pooled RR 1.58 [95% CI 1.38-1.81]). The diabetesassociated RRs for vascular dementia were 2.34 (95% CI 1.86-2.94) in women and 1.73 (95% CI 1.61-1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35-1.73) in women and 1.49 (95% CI 1.31-1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08-1.30]; P <0.001). Conclusions Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.

AB - Objective Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a metaanalysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. Research Design and Methods A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. Results Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45-1.80]; men: pooled RR 1.58 [95% CI 1.38-1.81]). The diabetesassociated RRs for vascular dementia were 2.34 (95% CI 1.86-2.94) in women and 1.73 (95% CI 1.61-1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35-1.73) in women and 1.49 (95% CI 1.31-1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08-1.30]; P <0.001). Conclusions Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.

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