Ubiquitin conjugating enzymes in the regulation of the autophagy-dependent degradation pathway

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The ubiquitin-proteasomal system and the autophagy-lysosome system are two major degradation systems in mammalian cells. Ubiquitin not only regulates proteasomal degradation of substrates but also regulates the autophagy pathway. In one type of macroautophagy, called selective autophagy, cargos are recruited to phagophore in a ubiquitin-dependent manner. Ubiquitin can target autophagy regulators for proteasomal degradation, control protein conformation or change interacting partners of these regulators. To understand the regulatory mechanisms of these degradation pathways, it is critical to dissect how the ubiquitin system contributes to them. Since enzymes are key regulators of ubiquitination, in this review, such enzymes in autophagy regulation are discussed, with specific focus on ubiquitin conjugating enzyme E2s, of which roles in autophagy are emerging.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalMatrix Biology
Volume100-101
DOIs
Publication statusPublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • Molecular Biology

Fingerprint

Dive into the research topics of 'Ubiquitin conjugating enzymes in the regulation of the autophagy-dependent degradation pathway'. Together they form a unique fingerprint.

Cite this