Ubiquitin-immunoreactive skein-like inclusions in the neostriatum are not restricted to amyotrophic lateral sclerosis, but are rather aging-related structures

Toshiro Kawashima, Akiko Furuta, Katsumi Doh-Ura, Hitoshi Kikuchi, Toru Iwaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We examined the presence of ubiquitin-immunoreactive skein-like inclusions (SLI) in the neostriatum and spinal cord in normal individuals and patients with different neurodegenerative diseases. Ubiquitin-immunoreactive SLI in the neostriatum were observed both in the normal individuals and in the patients with a variety of neurodegenerative diseases. In particular, SLI were frequently seen in normal aged subjects and certain neurodegenerative diseases, such as progressive supranuclear palsy and myotonic dystrophy. In contrast, the occurrence rate of SLI in cases with Pick's disease and multiple system atrophy tended to decrease. On the other hand, SLI in the spinal anterior horn were detected in cases of amyotrophic lateral sclerosis, but not in any cases with other neurodegenerative diseases. SLI in the neostriatum were also identifiable using phosphotungstic acid-hematoxylin and Gomori trichrome staining. Ubiquitin immunoelectron microscopy demonstrated that the SLI in the neostriatum corresponded to bundles of filaments. These features of SLI in the neostriatum were quite similar to those of intracytoplasmic rod-like inclusions (RLI) in the large neurons of caudate nucleus, which were first described by Kojima and Ogawa in 1974. Our findings indicate that SLI in the neostriatum are ubiquitin-related structures whose occurrence increases by aging, and less frequently accompany several neurodegenerative diseases, and are identical to at least some RLI.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalActa neuropathologica
Volume100
Issue number1
DOIs
Publication statusPublished - Jul 1 2000

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Neostriatum
Amyotrophic Lateral Sclerosis
Ubiquitin
Neurodegenerative Diseases
Pick Disease of the Brain
Phosphotungstic Acid
Progressive Supranuclear Palsy
Multiple System Atrophy
Myotonic Dystrophy
Immunoelectron Microscopy
Caudate Nucleus
Hematoxylin
Horns
Spinal Cord
Staining and Labeling
Neurons

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Ubiquitin-immunoreactive skein-like inclusions in the neostriatum are not restricted to amyotrophic lateral sclerosis, but are rather aging-related structures. / Kawashima, Toshiro; Furuta, Akiko; Doh-Ura, Katsumi; Kikuchi, Hitoshi; Iwaki, Toru.

In: Acta neuropathologica, Vol. 100, No. 1, 01.07.2000, p. 43-49.

Research output: Contribution to journalArticle

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