UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan

Yoshihiro Miyake, Keiko Tanaka, Wakaba Fukushima, Chikako Kiyohara, Satoshi Sasaki, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Hiroyuki Shimada, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota, Masaki Nagai, Yasuhiko Baba, Tomonori Kobayashi, Hideyuki Sawada, Eiji Mizuta, Nagako Murase, Tsuyoshi TsutadaTakami Miki, Jun Ichi Kira, Tameko Kihira, Tomoyoshi Kondo, Hidekazu Tomimoto, Takayuki Taniwaki, Hiroshi Sugiyama, Sonoyo Yoshida, Harutoshi Fujimura, Tomoko Saito, Kyoko Saida, Junko Fujitake, Naoki Fujii, Masatoshi Naito, Jun Arimizu, Takashi Nakagawa, Hirofumi Harada, Takayuki Sueta, Toshihiro Kikuta, George Umemoto, Eiichi Uchio, Hironori Migita, Kenichi Kazuki, Yoichi Ito, Hiroyoshi Iwaki, Kunihiko Siraki, Shinsuke Ataka, Hideo Yamane, Rie Tochino, Teruichi Harada, Yasushi Iwashita, Motoyuki Shimizu, Kenji Seki, Keiji Ando

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: A recent meta-analysis on the UCHL1 S18Y variant and Parkinson's disease (PD) showed a significant inverse association between the Y allele and PD; the individual studies included in that meta-analysis, however, have produced conflicting results. We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan.Methods: Included were 229 cases within 6 years of onset of PD, defined according to the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 357 inpatients and outpatients without neurodegenerative disease. Adjustment was made for sex, age, region of residence, smoking, and caffeine intake.Results: Compared with subjects with the CC or CA genotype of UCHL1 S18Y SNP, those with the AA genotype had a significantly increased risk of sporadic PD: the adjusted OR was 1.57 (95 % CI: 1.06 - 2.31). Compared with subjects with the CC or CA genotype of UCHL1 S18Y and the CC or CT genotype of SNCA SNP rs356220, those with the AA genotype of UCHL1 S18Y and the TT genotype of SNP rs356220 had a significantly increased risk of sporadic PD; the interaction, however, was not significant. Our previous investigation found significant inverse relationships between smoking and caffeine intake and PD in this population. There were no significant interactions between UCHL1 S18Y and smoking or caffeine intake affecting sporadic PD.Conclusions: This study reveals that the UCHL1 S18Y variant is a risk factor for sporadic PD. We could not find evidence for interactions affecting sporadic PD between UCHL1 S18Y and SNCA SNP rs356220, smoking, or caffeine intake.

Original languageEnglish
Article number62
JournalBMC neurology
Volume12
DOIs
Publication statusPublished - Jul 28 2012

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Parkinson Disease
Japan
Single Nucleotide Polymorphism
Genotype
Caffeine
Smoking
Meta-Analysis
Social Adjustment
Neurodegenerative Diseases
Inpatients
Outpatients
Alleles
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Miyake, Y., Tanaka, K., Fukushima, W., Kiyohara, C., Sasaki, S., Tsuboi, Y., ... Ando, K. (2012). UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan. BMC neurology, 12, [62]. https://doi.org/10.1186/1471-2377-12-62

UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan. / Miyake, Yoshihiro; Tanaka, Keiko; Fukushima, Wakaba; Kiyohara, Chikako; Sasaki, Satoshi; Tsuboi, Yoshio; Yamada, Tatsuo; Oeda, Tomoko; Shimada, Hiroyuki; Kawamura, Nobutoshi; Sakae, Nobutaka; Fukuyama, Hidenao; Hirota, Yoshio; Nagai, Masaki; Baba, Yasuhiko; Kobayashi, Tomonori; Sawada, Hideyuki; Mizuta, Eiji; Murase, Nagako; Tsutada, Tsuyoshi; Miki, Takami; Kira, Jun Ichi; Kihira, Tameko; Kondo, Tomoyoshi; Tomimoto, Hidekazu; Taniwaki, Takayuki; Sugiyama, Hiroshi; Yoshida, Sonoyo; Fujimura, Harutoshi; Saito, Tomoko; Saida, Kyoko; Fujitake, Junko; Fujii, Naoki; Naito, Masatoshi; Arimizu, Jun; Nakagawa, Takashi; Harada, Hirofumi; Sueta, Takayuki; Kikuta, Toshihiro; Umemoto, George; Uchio, Eiichi; Migita, Hironori; Kazuki, Kenichi; Ito, Yoichi; Iwaki, Hiroyoshi; Siraki, Kunihiko; Ataka, Shinsuke; Yamane, Hideo; Tochino, Rie; Harada, Teruichi; Iwashita, Yasushi; Shimizu, Motoyuki; Seki, Kenji; Ando, Keiji.

In: BMC neurology, Vol. 12, 62, 28.07.2012.

Research output: Contribution to journalArticle

Miyake, Y, Tanaka, K, Fukushima, W, Kiyohara, C, Sasaki, S, Tsuboi, Y, Yamada, T, Oeda, T, Shimada, H, Kawamura, N, Sakae, N, Fukuyama, H, Hirota, Y, Nagai, M, Baba, Y, Kobayashi, T, Sawada, H, Mizuta, E, Murase, N, Tsutada, T, Miki, T, Kira, JI, Kihira, T, Kondo, T, Tomimoto, H, Taniwaki, T, Sugiyama, H, Yoshida, S, Fujimura, H, Saito, T, Saida, K, Fujitake, J, Fujii, N, Naito, M, Arimizu, J, Nakagawa, T, Harada, H, Sueta, T, Kikuta, T, Umemoto, G, Uchio, E, Migita, H, Kazuki, K, Ito, Y, Iwaki, H, Siraki, K, Ataka, S, Yamane, H, Tochino, R, Harada, T, Iwashita, Y, Shimizu, M, Seki, K & Ando, K 2012, 'UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan', BMC neurology, vol. 12, 62. https://doi.org/10.1186/1471-2377-12-62
Miyake, Yoshihiro ; Tanaka, Keiko ; Fukushima, Wakaba ; Kiyohara, Chikako ; Sasaki, Satoshi ; Tsuboi, Yoshio ; Yamada, Tatsuo ; Oeda, Tomoko ; Shimada, Hiroyuki ; Kawamura, Nobutoshi ; Sakae, Nobutaka ; Fukuyama, Hidenao ; Hirota, Yoshio ; Nagai, Masaki ; Baba, Yasuhiko ; Kobayashi, Tomonori ; Sawada, Hideyuki ; Mizuta, Eiji ; Murase, Nagako ; Tsutada, Tsuyoshi ; Miki, Takami ; Kira, Jun Ichi ; Kihira, Tameko ; Kondo, Tomoyoshi ; Tomimoto, Hidekazu ; Taniwaki, Takayuki ; Sugiyama, Hiroshi ; Yoshida, Sonoyo ; Fujimura, Harutoshi ; Saito, Tomoko ; Saida, Kyoko ; Fujitake, Junko ; Fujii, Naoki ; Naito, Masatoshi ; Arimizu, Jun ; Nakagawa, Takashi ; Harada, Hirofumi ; Sueta, Takayuki ; Kikuta, Toshihiro ; Umemoto, George ; Uchio, Eiichi ; Migita, Hironori ; Kazuki, Kenichi ; Ito, Yoichi ; Iwaki, Hiroyoshi ; Siraki, Kunihiko ; Ataka, Shinsuke ; Yamane, Hideo ; Tochino, Rie ; Harada, Teruichi ; Iwashita, Yasushi ; Shimizu, Motoyuki ; Seki, Kenji ; Ando, Keiji. / UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan. In: BMC neurology. 2012 ; Vol. 12.
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abstract = "Background: A recent meta-analysis on the UCHL1 S18Y variant and Parkinson's disease (PD) showed a significant inverse association between the Y allele and PD; the individual studies included in that meta-analysis, however, have produced conflicting results. We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan.Methods: Included were 229 cases within 6 years of onset of PD, defined according to the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 357 inpatients and outpatients without neurodegenerative disease. Adjustment was made for sex, age, region of residence, smoking, and caffeine intake.Results: Compared with subjects with the CC or CA genotype of UCHL1 S18Y SNP, those with the AA genotype had a significantly increased risk of sporadic PD: the adjusted OR was 1.57 (95 {\%} CI: 1.06 - 2.31). Compared with subjects with the CC or CA genotype of UCHL1 S18Y and the CC or CT genotype of SNCA SNP rs356220, those with the AA genotype of UCHL1 S18Y and the TT genotype of SNP rs356220 had a significantly increased risk of sporadic PD; the interaction, however, was not significant. Our previous investigation found significant inverse relationships between smoking and caffeine intake and PD in this population. There were no significant interactions between UCHL1 S18Y and smoking or caffeine intake affecting sporadic PD.Conclusions: This study reveals that the UCHL1 S18Y variant is a risk factor for sporadic PD. We could not find evidence for interactions affecting sporadic PD between UCHL1 S18Y and SNCA SNP rs356220, smoking, or caffeine intake.",
author = "Yoshihiro Miyake and Keiko Tanaka and Wakaba Fukushima and Chikako Kiyohara and Satoshi Sasaki and Yoshio Tsuboi and Tatsuo Yamada and Tomoko Oeda and Hiroyuki Shimada and Nobutoshi Kawamura and Nobutaka Sakae and Hidenao Fukuyama and Yoshio Hirota and Masaki Nagai and Yasuhiko Baba and Tomonori Kobayashi and Hideyuki Sawada and Eiji Mizuta and Nagako Murase and Tsuyoshi Tsutada and Takami Miki and Kira, {Jun Ichi} and Tameko Kihira and Tomoyoshi Kondo and Hidekazu Tomimoto and Takayuki Taniwaki and Hiroshi Sugiyama and Sonoyo Yoshida and Harutoshi Fujimura and Tomoko Saito and Kyoko Saida and Junko Fujitake and Naoki Fujii and Masatoshi Naito and Jun Arimizu and Takashi Nakagawa and Hirofumi Harada and Takayuki Sueta and Toshihiro Kikuta and George Umemoto and Eiichi Uchio and Hironori Migita and Kenichi Kazuki and Yoichi Ito and Hiroyoshi Iwaki and Kunihiko Siraki and Shinsuke Ataka and Hideo Yamane and Rie Tochino and Teruichi Harada and Yasushi Iwashita and Motoyuki Shimizu and Kenji Seki and Keiji Ando",
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T1 - UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan

AU - Miyake, Yoshihiro

AU - Tanaka, Keiko

AU - Fukushima, Wakaba

AU - Kiyohara, Chikako

AU - Sasaki, Satoshi

AU - Tsuboi, Yoshio

AU - Yamada, Tatsuo

AU - Oeda, Tomoko

AU - Shimada, Hiroyuki

AU - Kawamura, Nobutoshi

AU - Sakae, Nobutaka

AU - Fukuyama, Hidenao

AU - Hirota, Yoshio

AU - Nagai, Masaki

AU - Baba, Yasuhiko

AU - Kobayashi, Tomonori

AU - Sawada, Hideyuki

AU - Mizuta, Eiji

AU - Murase, Nagako

AU - Tsutada, Tsuyoshi

AU - Miki, Takami

AU - Kira, Jun Ichi

AU - Kihira, Tameko

AU - Kondo, Tomoyoshi

AU - Tomimoto, Hidekazu

AU - Taniwaki, Takayuki

AU - Sugiyama, Hiroshi

AU - Yoshida, Sonoyo

AU - Fujimura, Harutoshi

AU - Saito, Tomoko

AU - Saida, Kyoko

AU - Fujitake, Junko

AU - Fujii, Naoki

AU - Naito, Masatoshi

AU - Arimizu, Jun

AU - Nakagawa, Takashi

AU - Harada, Hirofumi

AU - Sueta, Takayuki

AU - Kikuta, Toshihiro

AU - Umemoto, George

AU - Uchio, Eiichi

AU - Migita, Hironori

AU - Kazuki, Kenichi

AU - Ito, Yoichi

AU - Iwaki, Hiroyoshi

AU - Siraki, Kunihiko

AU - Ataka, Shinsuke

AU - Yamane, Hideo

AU - Tochino, Rie

AU - Harada, Teruichi

AU - Iwashita, Yasushi

AU - Shimizu, Motoyuki

AU - Seki, Kenji

AU - Ando, Keiji

PY - 2012/7/28

Y1 - 2012/7/28

N2 - Background: A recent meta-analysis on the UCHL1 S18Y variant and Parkinson's disease (PD) showed a significant inverse association between the Y allele and PD; the individual studies included in that meta-analysis, however, have produced conflicting results. We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan.Methods: Included were 229 cases within 6 years of onset of PD, defined according to the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 357 inpatients and outpatients without neurodegenerative disease. Adjustment was made for sex, age, region of residence, smoking, and caffeine intake.Results: Compared with subjects with the CC or CA genotype of UCHL1 S18Y SNP, those with the AA genotype had a significantly increased risk of sporadic PD: the adjusted OR was 1.57 (95 % CI: 1.06 - 2.31). Compared with subjects with the CC or CA genotype of UCHL1 S18Y and the CC or CT genotype of SNCA SNP rs356220, those with the AA genotype of UCHL1 S18Y and the TT genotype of SNP rs356220 had a significantly increased risk of sporadic PD; the interaction, however, was not significant. Our previous investigation found significant inverse relationships between smoking and caffeine intake and PD in this population. There were no significant interactions between UCHL1 S18Y and smoking or caffeine intake affecting sporadic PD.Conclusions: This study reveals that the UCHL1 S18Y variant is a risk factor for sporadic PD. We could not find evidence for interactions affecting sporadic PD between UCHL1 S18Y and SNCA SNP rs356220, smoking, or caffeine intake.

AB - Background: A recent meta-analysis on the UCHL1 S18Y variant and Parkinson's disease (PD) showed a significant inverse association between the Y allele and PD; the individual studies included in that meta-analysis, however, have produced conflicting results. We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan.Methods: Included were 229 cases within 6 years of onset of PD, defined according to the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 357 inpatients and outpatients without neurodegenerative disease. Adjustment was made for sex, age, region of residence, smoking, and caffeine intake.Results: Compared with subjects with the CC or CA genotype of UCHL1 S18Y SNP, those with the AA genotype had a significantly increased risk of sporadic PD: the adjusted OR was 1.57 (95 % CI: 1.06 - 2.31). Compared with subjects with the CC or CA genotype of UCHL1 S18Y and the CC or CT genotype of SNCA SNP rs356220, those with the AA genotype of UCHL1 S18Y and the TT genotype of SNP rs356220 had a significantly increased risk of sporadic PD; the interaction, however, was not significant. Our previous investigation found significant inverse relationships between smoking and caffeine intake and PD in this population. There were no significant interactions between UCHL1 S18Y and smoking or caffeine intake affecting sporadic PD.Conclusions: This study reveals that the UCHL1 S18Y variant is a risk factor for sporadic PD. We could not find evidence for interactions affecting sporadic PD between UCHL1 S18Y and SNCA SNP rs356220, smoking, or caffeine intake.

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