Ultra-short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice

Masaya Takahashi, Osamu Togao, Makoto Obara, Marc Van Cauteren, Yoshiharu Ohno, Shigehiro Doi, Makoto Kuro-o, Craig Malloy, Connie C. Hsia, Ivan Dimitrov

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the utility of ultra-short echo time (UTE) sequence as pulmonary MRI to detect non-uniform disruption of lung architecture that is typical of emphysema. Materials and Methods: MRI of the lungs was conducted with a three-dimensional UTE sequence in transgenic mice with severe emphysema and their wild-type litter-mates in a 3 Tesla clinical MR system. Measurements of the signal intensity (SI) and transverse relaxation time (T2*) of the lung parenchyma were performed with various echo times (TEs) ranging from 100 μs to 2 ms. Results: Much higher SI of the lung parenchyma was observed at an UTE of 100 μs compared with longer TEs. The emphysematous lungs had reduced SIs and T2* than the controls, in particular at end-expiratory phase. The results suggested that both SI and T2* in lung parenchyma measured with the method represent fractional volume of lung tissue. Conclusion: The UTE imaging provided MR signal from the lung parenchyma. Moreover, the UTE sequence was sensitive to emphysematous changes and may provide a direct assessment of lung parenchyma. UTE imaging has the potential to assist detection of localized pathological destruction of lung tissue architecture in emphysema.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume32
Issue number2
DOIs
Publication statusPublished - Aug 1 2010
Externally publishedYes

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Lung
Emphysema
Transgenic Mice

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Ultra-short echo time (UTE) MR imaging of the lung : Comparison between normal and emphysematous lungs in mutant mice. / Takahashi, Masaya; Togao, Osamu; Obara, Makoto; Van Cauteren, Marc; Ohno, Yoshiharu; Doi, Shigehiro; Kuro-o, Makoto; Malloy, Craig; Hsia, Connie C.; Dimitrov, Ivan.

In: Journal of Magnetic Resonance Imaging, Vol. 32, No. 2, 01.08.2010, p. 326-333.

Research output: Contribution to journalArticle

Takahashi, M, Togao, O, Obara, M, Van Cauteren, M, Ohno, Y, Doi, S, Kuro-o, M, Malloy, C, Hsia, CC & Dimitrov, I 2010, 'Ultra-short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice', Journal of Magnetic Resonance Imaging, vol. 32, no. 2, pp. 326-333. https://doi.org/10.1002/jmri.22267
Takahashi, Masaya ; Togao, Osamu ; Obara, Makoto ; Van Cauteren, Marc ; Ohno, Yoshiharu ; Doi, Shigehiro ; Kuro-o, Makoto ; Malloy, Craig ; Hsia, Connie C. ; Dimitrov, Ivan. / Ultra-short echo time (UTE) MR imaging of the lung : Comparison between normal and emphysematous lungs in mutant mice. In: Journal of Magnetic Resonance Imaging. 2010 ; Vol. 32, No. 2. pp. 326-333.
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