Ultrahigh hardness and biocompatibility of high-entropy alloy TiAlFeCoNi processed by high-pressure torsion

Parisa Edalati, Ricardo Floriano, Yongpeng Tang, Abbas Mohammadi, Karina Danielle Pereira, Augusto Ducati Luchessi, Kaveh Edalati

Research output: Contribution to journalArticle


Despite significant studies on mechanical properties of high-entropy alloys (HEAs), there have been limited attempts to examine the biocompatibility of these alloys. In this study, a lattice-softened high-entropy alloy TiAlFeCoNi with ultrahigh hardness (examined by Vickers method), low elastic modulus (examined by nanoindentation) and superior activity for cell proliferation/viability/cytotoxicity (examined by MTT assay) was developed by employing imperial data and thermodynamic calculations. The designated alloy after casting was processed further by high-pressure torsion (HPT) to improve its hardness via the introduction of nanograins, dislocations and order-disorder transformation. The TiAlFeCoNi alloy with the L21-BCC crystal structure exhibited 170–580% higher hardness and 260–1020% better cellular metabolic activity compared to titanium and Ti-6Al-7Nb biomaterials, suggesting the high potential of HEAs for future biomedical applications.

Original languageEnglish
Article number110908
JournalMaterials Science and Engineering C
Publication statusPublished - Jul 2020


All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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