TY - JOUR
T1 - Ultrasonic implantation of calcium metasilicate glass particles into PMMA
AU - Tsuru, K.
AU - Hayakawa, S.
AU - Ohtsuki, C.
AU - Osaka, A.
N1 - Funding Information:
Financial support by a Grant-in-Aid for Developmental Scientific Research, Ministry of Education, Culture, Science and Sports, Japan (06555186), is acknowledged. The authors are grateful to Professor Tadashi Kokubo, Kyoto University, for allowing them to use the X-ray diffraction facility.
PY - 1998/8
Y1 - 1998/8
N2 - Polymer materials for clinical applications should be bioactive and have a bone-bonding ability. In order to provide poly(methyl methacrylate) (PMMA) with bioactivity, granules ( < 45 μm) of a bioactive glass 50CaO.50SiO2 (mol %) were implanted into PMMA: they were suspended together with a piece of PMMA in a 40 tetrahydrofuran-60 ethanol (vol %) solution and ultrasonically agitated. The granules of < 10 μm in size were impregnated at ~ 40-20 μm depth below the substrate surface. Two types were detected on the PMMA surface: (a) a glass-granule layer on PMMA, and (b) an inner granule layer, a PMMA layer, and an outer granule layer on the PMMA. The bioactivity of the implanted PMMA substrates was examined in vitro with a simulated body fluid (Kokubo solution). Apatite was precipitated on all glass granules and the whole substrate surfaces within 1 d. After 4 h soaking in the Kokubo solution, aggregates of apatite particles appeared on the substrate surface, independently of those on the glass granules, and they grew and proliferated on the whole subtrate surface in 7 d. Silica gel islands on PMMA due to the silicate anions from the glass were considered to induce nucleation of the apatite particles.
AB - Polymer materials for clinical applications should be bioactive and have a bone-bonding ability. In order to provide poly(methyl methacrylate) (PMMA) with bioactivity, granules ( < 45 μm) of a bioactive glass 50CaO.50SiO2 (mol %) were implanted into PMMA: they were suspended together with a piece of PMMA in a 40 tetrahydrofuran-60 ethanol (vol %) solution and ultrasonically agitated. The granules of < 10 μm in size were impregnated at ~ 40-20 μm depth below the substrate surface. Two types were detected on the PMMA surface: (a) a glass-granule layer on PMMA, and (b) an inner granule layer, a PMMA layer, and an outer granule layer on the PMMA. The bioactivity of the implanted PMMA substrates was examined in vitro with a simulated body fluid (Kokubo solution). Apatite was precipitated on all glass granules and the whole substrate surfaces within 1 d. After 4 h soaking in the Kokubo solution, aggregates of apatite particles appeared on the substrate surface, independently of those on the glass granules, and they grew and proliferated on the whole subtrate surface in 7 d. Silica gel islands on PMMA due to the silicate anions from the glass were considered to induce nucleation of the apatite particles.
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U2 - 10.1023/A:1008875502451
DO - 10.1023/A:1008875502451
M3 - Article
C2 - 15348861
AN - SCOPUS:0032144091
SN - 0957-4522
VL - 9
SP - 479
EP - 484
JO - Journal of Materials Science: Materials in Electronics
JF - Journal of Materials Science: Materials in Electronics
IS - 8
ER -