Ultrastructure of the internal limiting membrane of the retina over the area of lattice degeneration

Y. Ohnishi, T. Kohno, T. Ishibashi

Research output: Contribution to journalArticle

Abstract

Purpose. Lattice degeneration of the retina is associated with rhegmatogenous retinal detachment, and there is no internal limiting membrane(ILM) of the retina over the area of the lattice. It is widely accepted that this ILM defect may be congenital and be the primary cause of lattice degeneration. We carried out an ultrastruclural study on ILM, and related mechanisms were examined. Patients and Methods. In 58 eyes enucleated in the Department of Ophthalmology, Kyushu University Hospital were examined, under a dissecting microscope, and lattice degeneration was present in 4 men, and one woman. Ages ranged from 43, 55, 65, 66 and 77 year,respectively. Enucleation was done for orbital menigioma, autopsy,squamous cell carcinoma of the orbit, autopsy and orbital aspergillosis, respectively.These eyes were fixed, dissected, appropriately embedded and observed under light and electron microscopes. Results. Histopathologic findings included:(1)retinal thinning and gliosis,(2) condensation and liquefaction of the overlying vitreous,(3)vitreoretinal adhesion at the border of the lesion,(4)thick, hyalinized retinal vessels,(5) no ILM,(6)irregular and a mottled retinal pigment epithelium etc. In some areas of the lattice degeneration, ILM was separated from the retina by the traction of the vitreous. Conclusions. These observations suggest that the defect of ILM may be acquired and may not be the primary cause of lattice degeneration.

Original languageEnglish
Pages (from-to)S495
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
Publication statusPublished - Feb 15 1996

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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