Ultrastructure of the trabecular meshwork in secondary glaucoma eyes after intravitreal triamcinolone acetonide

Toshiaki Kubota, Hakuoh Okabe, Toshio Hisatomi, Keita Yamakiri, Taiji Sakamoto, Ahihiko Tawara

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Purpose: To study the histology of the trabecular meshwork of eyes with glaucoma by intravitreal injection of triamcinolone acetonide (TA). Design: Two cases report. Participants/Methods: A 68-year-old Japanese man with branch retinal vein occlusion and a 48-year-old Japanese woman with uveitis were treated by cataract surgery, intraocular lens implantation, and TA-assisted pars plana vitrectomy. At the end of surgery, TA suspension (4mg) was intravitreously injected. During the follow-up period, the intraocular pressure (IOP) of the patients increased over 30mm Hg even with full medication. Trabeculectomy was performed at 4 months after TA injection in case 1 and at 6 months in case 2, and intraocular pressure returned to the normal range in both cases. Light and electron microscopic studies of the resected trabecular tissue were carried out. Results: The histology showed minimal deposition of extracellular matrix in the trabecular meshwork in case 1. Case 2 showed the beginnings of deposition of extracellular matrix including fingerprintlike material in the trabecular meshwork with decreased intertrabecular spaces. Conclusions: The ultrastructural changes in the trabecular meshwork of eyes with glaucoma after treatment with intravitreal TA might resemble those with glaucoma after topical corticosteroid treatment.

Original languageEnglish
Pages (from-to)117-119
Number of pages3
JournalJournal of Glaucoma
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2006

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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