Understanding endothelial cell apoptosis: What can the transcriptome, glycome and proteome reveal?

Muna Affara, Benjamin Dunmore, Christopher Savoie, Seiya Imoto, Yoshinori Tamada, Hiromitsu Araki, D. Stephen Charnock-Jones, Satoru Miyano, Cristin Print

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Endothelial cell (EC) apoptosis may play an important role in blood vessel development, homeostasis and remodelling. In support of this concept, EC apoptosis has been detected within remodelling vessels in vivo, and inactivation of EC apoptosis regulators has caused dramatic vascular phenotypes. EC apoptosis has also been associated with cardiovascular pathologies. Therefore, understanding the regulation of EC apoptosis, with the goal of intervening in this process, has become a current research focus. The protein-based signalling and cleavage cascades that regulate EC apoptosis are well known. However, the possibility that programmed transcriptome and glycome changes contribute to EC apoptosis has only recently been explored. Traditional bioinformatic techniques have allowed simultaneous study of thousands of molecular signals during the process of EC apoptosis. However, to progress further, we now need to understand the complex cause and effect relationships among these signals. In this article, we will first review current knowledge about the function and regulation of EC apoptosis including the roles of the proteome transcriptome and glycome. Then, we assess the potential for further bioinformatic analysis to advance our understanding of EC apoptosis, including the limitations of current technologies and the potential of emerging technologies such as gene regulatory networks.

Original languageEnglish
Pages (from-to)1469-1487
Number of pages19
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume362
Issue number1484
DOIs
Publication statusPublished - Aug 29 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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