TY - JOUR
T1 - Unexpectedly long half-lives of blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) levels in Yusho patients
AU - Matsumoto, Shinya
AU - Akahane, Manabu
AU - Kanagawa, Yoshiyuki
AU - Kajiwara, Jumboku
AU - Mitoma, Chikage
AU - Uchi, Hiroshi
AU - Furue, Masutaka
AU - Imamura, Tomoaki
N1 - Funding Information:
This research was supported by a Grant-in-Aid for scientific research from the Ministry of Health, Labour and Welfare, Japan.
Publisher Copyright:
© 2015 Matsumoto et al.
PY - 2015/9/17
Y1 - 2015/9/17
N2 - Background: Dioxins and dioxin-like compounds have half-lives typically between 7.2 years and 15 years. Our previous study of patients poisoned by extremely high concentrations of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) in the 'Yusho incident' in 1968 found that in some the half-life of blood 2,3,4,7,8-PeCDF tended towards infinity. This suggests that there are two groups of Yusho patients, those with 2,3,4,7,8-PeCDF half-lives around 10 years, and those with half-lives near infinity. We sought to establish the proportions of each in a cohort of 395 Yusho patients, and whether the proportions were changing over time. Methods: We undertook longitudinal measurement of the blood concentration of 2,3,4,7,8-PeCDF in our cohort between 2002 and 2010. We estimated the change in concentration for each patient using linear regression for measured 2,3,4,7,8-PeCDF concentration, then compared the distribution of changes in concentrations with our previous study. Results: In patients in whom the blood concentration of 2,3,4,7,8-PeCDF exceeded 50 pg/g lipid, the proportion 8.0 % of patients exhibiting half-lives less than 13.3 years fell compared with our previous study (28.2 %), while the proportion with near infinity half-lives increased. Conclusion: The prolongation of the half-lives was likely a consequence of age-related factors.
AB - Background: Dioxins and dioxin-like compounds have half-lives typically between 7.2 years and 15 years. Our previous study of patients poisoned by extremely high concentrations of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) in the 'Yusho incident' in 1968 found that in some the half-life of blood 2,3,4,7,8-PeCDF tended towards infinity. This suggests that there are two groups of Yusho patients, those with 2,3,4,7,8-PeCDF half-lives around 10 years, and those with half-lives near infinity. We sought to establish the proportions of each in a cohort of 395 Yusho patients, and whether the proportions were changing over time. Methods: We undertook longitudinal measurement of the blood concentration of 2,3,4,7,8-PeCDF in our cohort between 2002 and 2010. We estimated the change in concentration for each patient using linear regression for measured 2,3,4,7,8-PeCDF concentration, then compared the distribution of changes in concentrations with our previous study. Results: In patients in whom the blood concentration of 2,3,4,7,8-PeCDF exceeded 50 pg/g lipid, the proportion 8.0 % of patients exhibiting half-lives less than 13.3 years fell compared with our previous study (28.2 %), while the proportion with near infinity half-lives increased. Conclusion: The prolongation of the half-lives was likely a consequence of age-related factors.
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U2 - 10.1186/s12940-015-0059-y
DO - 10.1186/s12940-015-0059-y
M3 - Article
C2 - 26384313
AN - SCOPUS:84941773744
SN - 1476-069X
VL - 14
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
IS - 1
M1 - 76
ER -
