Abstract
Regeneration phenomena are ubiquitous in nature and are studied in a variety of experiments. Positional information and feedback-loop hierarchy are theories that have been proposed to explain ordering rules in regeneration; however, some regeneration phenomena violate the rules derived from them. In particular, grafted junction stumps with the same value/hierarchy sometimes lead to one extra segmented portion, termed segmented regeneration. To present a unified description of all insect leg regeneration phenomena, we propose a theoretical mechanism for regeneration without postulating positional information, by using a model that consists of intracellular reaction dynamics of chemical concentrations, cell-to-cell interactions, and an increase in cell number. As a normal developmental process, successive differentiation from pluripotent cells appears, as described by transition from cells with intracellular chaotic dynamics to those with oscillatory or fixed-point dynamics. By assigning chaotic and nonchaotic cell types to corresponding positions instead of positional information, intercalary, segmented, and tarsus regeneration are explained coherently. With this assignment of pluripotency to chaotic dynamics, a unified description of regeneration is obtained with some predictive value for new experiments.
| Original language | English |
|---|---|
| Pages (from-to) | 1974-1983 |
| Number of pages | 10 |
| Journal | Developmental Dynamics |
| Volume | 238 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2008 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
Cite this
Unified description of regeneration by coupled dynamical systems theory : Intercalary/segmented regeneration in insect legs. / Yoshida, Hiroshi; Kaneko, Kunihiko.
In: Developmental Dynamics, Vol. 238, No. 8, 08.2008, p. 1974-1983.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unified description of regeneration by coupled dynamical systems theory
T2 - Intercalary/segmented regeneration in insect legs
AU - Yoshida, Hiroshi
AU - Kaneko, Kunihiko
PY - 2008/8
Y1 - 2008/8
N2 - Regeneration phenomena are ubiquitous in nature and are studied in a variety of experiments. Positional information and feedback-loop hierarchy are theories that have been proposed to explain ordering rules in regeneration; however, some regeneration phenomena violate the rules derived from them. In particular, grafted junction stumps with the same value/hierarchy sometimes lead to one extra segmented portion, termed segmented regeneration. To present a unified description of all insect leg regeneration phenomena, we propose a theoretical mechanism for regeneration without postulating positional information, by using a model that consists of intracellular reaction dynamics of chemical concentrations, cell-to-cell interactions, and an increase in cell number. As a normal developmental process, successive differentiation from pluripotent cells appears, as described by transition from cells with intracellular chaotic dynamics to those with oscillatory or fixed-point dynamics. By assigning chaotic and nonchaotic cell types to corresponding positions instead of positional information, intercalary, segmented, and tarsus regeneration are explained coherently. With this assignment of pluripotency to chaotic dynamics, a unified description of regeneration is obtained with some predictive value for new experiments.
AB - Regeneration phenomena are ubiquitous in nature and are studied in a variety of experiments. Positional information and feedback-loop hierarchy are theories that have been proposed to explain ordering rules in regeneration; however, some regeneration phenomena violate the rules derived from them. In particular, grafted junction stumps with the same value/hierarchy sometimes lead to one extra segmented portion, termed segmented regeneration. To present a unified description of all insect leg regeneration phenomena, we propose a theoretical mechanism for regeneration without postulating positional information, by using a model that consists of intracellular reaction dynamics of chemical concentrations, cell-to-cell interactions, and an increase in cell number. As a normal developmental process, successive differentiation from pluripotent cells appears, as described by transition from cells with intracellular chaotic dynamics to those with oscillatory or fixed-point dynamics. By assigning chaotic and nonchaotic cell types to corresponding positions instead of positional information, intercalary, segmented, and tarsus regeneration are explained coherently. With this assignment of pluripotency to chaotic dynamics, a unified description of regeneration is obtained with some predictive value for new experiments.
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U2 - 10.1002/dvdy.22026
DO - 10.1002/dvdy.22026
M3 - Article
VL - 238
SP - 1974
EP - 1983
JO - Developmental Dynamics
JF - Developmental Dynamics
SN - 1058-8388
IS - 8
ER -