Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy

Hidenori Ogata, Noriko Isobe, Xu Zhang, Ryo Yamasaki, Takayuki Fujii, Akira Machida, Nobutoshi Morimoto, Kenichi Kaida, Teruaki Masuda, Yukio Ando, Motoi Kuwahara, Susumu Kusunoki, Yuri Nakamura, Takuya Matsushita, Jun ichi Kira

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Abstract

To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with those of healthy Japanese controls. All IgG4 anti-NF155 antibody-positive CIDP patients exclusively carried either HLA-DRB1*15:01-DRB5*01:01-DQA1*01:02-DQB1*06:02 or -(A*24:02)-B*52:01-C*12:02-DRB1*15:02-DRB5*01:02-DQA1*01:03-DQB1*06:01, resulting in significantly increased HLA-DRB1*15, -DRB1*15:01, -DQB1*06:01/06:02, -DQB1*06:02, and -DRB1*15:01-DQB1*06:02 frequencies compared with healthy Japanese controls. These findings indicate the involvement of specific HLA class II molecules in the pathomechanisms of IgG4 anti-NF155 antibody-positive CIDP.

Original languageEnglish
Article number577139
JournalJournal of Neuroimmunology
Volume339
DOIs
Publication statusPublished - Feb 15 2020

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
HLA Antigens
Haplotypes
Immunoglobulin G
Antibodies
Immunogenetics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy. / Ogata, Hidenori; Isobe, Noriko; Zhang, Xu; Yamasaki, Ryo; Fujii, Takayuki; Machida, Akira; Morimoto, Nobutoshi; Kaida, Kenichi; Masuda, Teruaki; Ando, Yukio; Kuwahara, Motoi; Kusunoki, Susumu; Nakamura, Yuri; Matsushita, Takuya; Kira, Jun ichi.

In: Journal of Neuroimmunology, Vol. 339, 577139, 15.02.2020.

Research output: Contribution to journalArticle

Ogata, Hidenori ; Isobe, Noriko ; Zhang, Xu ; Yamasaki, Ryo ; Fujii, Takayuki ; Machida, Akira ; Morimoto, Nobutoshi ; Kaida, Kenichi ; Masuda, Teruaki ; Ando, Yukio ; Kuwahara, Motoi ; Kusunoki, Susumu ; Nakamura, Yuri ; Matsushita, Takuya ; Kira, Jun ichi. / Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy. In: Journal of Neuroimmunology. 2020 ; Vol. 339.
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