Unparalleled rates for the activation of aryl chlorides and bromides: Coupling with amines and boronic acids in minutes at room temperature

James P. Stambuli, Ryoichi Kuwano, John F. Hartwig

Research output: Contribution to journalArticle

320 Citations (Scopus)

Abstract

Exceptionally fast oxidative addition of an aryl chloride (or a deactivated aryl bromide) to the active Pd0 center, which is ligated by sterically demanding phosphanes, occurs during coupling reactions catalyzed by air-stable Pd1 dimers as shown in the scheme. As a result, the reactions of aryl chlorides and bromides with amines and boronic acids at room temperature are complete within a few minutes. 1-Ad = 1-adamantyl.

Original languageEnglish
Pages (from-to)4746-4748
Number of pages3
JournalAngewandte Chemie - International Edition
Volume41
Issue number24
DOIs
Publication statusPublished - Dec 16 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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