TY - JOUR
T1 - Unparalleled rates for the activation of aryl chlorides and bromides
T2 - Coupling with amines and boronic acids in minutes at room temperature
AU - Stambuli, James P.
AU - Kuwano, Ryoichi
AU - Hartwig, John F.
PY - 2002/12/16
Y1 - 2002/12/16
N2 - Exceptionally fast oxidative addition of an aryl chloride (or a deactivated aryl bromide) to the active Pd0 center, which is ligated by sterically demanding phosphanes, occurs during coupling reactions catalyzed by air-stable Pd1 dimers as shown in the scheme. As a result, the reactions of aryl chlorides and bromides with amines and boronic acids at room temperature are complete within a few minutes. 1-Ad = 1-adamantyl.
AB - Exceptionally fast oxidative addition of an aryl chloride (or a deactivated aryl bromide) to the active Pd0 center, which is ligated by sterically demanding phosphanes, occurs during coupling reactions catalyzed by air-stable Pd1 dimers as shown in the scheme. As a result, the reactions of aryl chlorides and bromides with amines and boronic acids at room temperature are complete within a few minutes. 1-Ad = 1-adamantyl.
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U2 - 10.1002/anie.200290036
DO - 10.1002/anie.200290036
M3 - Article
C2 - 12481346
AN - SCOPUS:0037122141
VL - 41
SP - 4746
EP - 4748
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 24
ER -