Unparalleled rates for the activation of aryl chlorides and bromides: Coupling with amines and boronic acids in minutes at room temperature

James P. Stambuli; Ryoichi Kuwano; John F. Hartwig

doi:10.1002/anie.200290036

Unparalleled rates for the activation of aryl chlorides and bromides: Coupling with amines and boronic acids in minutes at room temperature

James P. Stambuli, Ryoichi Kuwano, John F. Hartwig

Research output: Contribution to journal › Article › peer-review

329 Citations (Scopus)

Abstract

Exceptionally fast oxidative addition of an aryl chloride (or a deactivated aryl bromide) to the active Pd⁰ center, which is ligated by sterically demanding phosphanes, occurs during coupling reactions catalyzed by air-stable Pd¹ dimers as shown in the scheme. As a result, the reactions of aryl chlorides and bromides with amines and boronic acids at room temperature are complete within a few minutes. 1-Ad = 1-adamantyl.

Original language	English
Pages (from-to)	4746-4748
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	24
DOIs	https://doi.org/10.1002/anie.200290036
Publication status	Published - Dec 16 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200290036

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