Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning

Shouichi Ohga, Kiyomi Ichino, Kazuna Goto, Sagano Hattori, Akihiko Nomura, Hidetoshi Takada, Katsumasa Nakamura, Toshiro Hara

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Treatment of severe aplastic anemia (SAA) patients who lack human leukocyte antigen (HLA)-matched donors and failed immunosuppressive therapy (IST) is challenging. Recently, umbilical cord blood transplantation (CBT) after non-myeloablative therapy has been reported in adult but not in childhood SAA. However, most cases resulted in mixed donor chimerism and incomplete hematological recovery. We reported an 11-yr-old girl with recurred SAA 5 yr after IST who underwent unrelated donor CBT after a modified regimen. This patient had renal and cardiac dysfunction, and lacked suitable bone marrow donors. The 3.9 × 107/kg CB cells from an HLA one-locus mismatched unrelated donor were infused after conditioning with total body irradiation (5 Gy), melphalan (120 mg/m2), and fludarabin (120 mg/m2). Hematological recovery was favorable in complete chimerism. A major complication was only skin graft-versus-host disease (grade I). CB could be an alternate stem cell source for childhood SAA after modified preparative regimen.

Original languageEnglish
Pages (from-to)497-500
Number of pages4
JournalPediatric Transplantation
Volume10
Issue number4
DOIs
Publication statusPublished - Jun 1 2006

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Unrelated Donors
Aplastic Anemia
Fetal Blood
Transplantation
Chimerism
Tissue Donors
Immunosuppressive Agents
HLA Antigens
Melphalan
Whole-Body Irradiation
Graft vs Host Disease
Therapeutics
Stem Cells
Bone Marrow
Kidney
Skin

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning. / Ohga, Shouichi; Ichino, Kiyomi; Goto, Kazuna; Hattori, Sagano; Nomura, Akihiko; Takada, Hidetoshi; Nakamura, Katsumasa; Hara, Toshiro.

In: Pediatric Transplantation, Vol. 10, No. 4, 01.06.2006, p. 497-500.

Research output: Contribution to journalArticle

Ohga, Shouichi ; Ichino, Kiyomi ; Goto, Kazuna ; Hattori, Sagano ; Nomura, Akihiko ; Takada, Hidetoshi ; Nakamura, Katsumasa ; Hara, Toshiro. / Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning. In: Pediatric Transplantation. 2006 ; Vol. 10, No. 4. pp. 497-500.
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