TY - JOUR
T1 - Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning
AU - Ohga, Shouichi
AU - Ichino, Kiyomi
AU - Goto, Kazuna
AU - Hattori, Sagano
AU - Nomura, Akihiko
AU - Takada, Hidetoshi
AU - Nakamura, Katsumasa
AU - Hara, Toshiro
PY - 2006/6
Y1 - 2006/6
N2 - Treatment of severe aplastic anemia (SAA) patients who lack human leukocyte antigen (HLA)-matched donors and failed immunosuppressive therapy (IST) is challenging. Recently, umbilical cord blood transplantation (CBT) after non-myeloablative therapy has been reported in adult but not in childhood SAA. However, most cases resulted in mixed donor chimerism and incomplete hematological recovery. We reported an 11-yr-old girl with recurred SAA 5 yr after IST who underwent unrelated donor CBT after a modified regimen. This patient had renal and cardiac dysfunction, and lacked suitable bone marrow donors. The 3.9 × 107/kg CB cells from an HLA one-locus mismatched unrelated donor were infused after conditioning with total body irradiation (5 Gy), melphalan (120 mg/m2), and fludarabin (120 mg/m2). Hematological recovery was favorable in complete chimerism. A major complication was only skin graft-versus-host disease (grade I). CB could be an alternate stem cell source for childhood SAA after modified preparative regimen.
AB - Treatment of severe aplastic anemia (SAA) patients who lack human leukocyte antigen (HLA)-matched donors and failed immunosuppressive therapy (IST) is challenging. Recently, umbilical cord blood transplantation (CBT) after non-myeloablative therapy has been reported in adult but not in childhood SAA. However, most cases resulted in mixed donor chimerism and incomplete hematological recovery. We reported an 11-yr-old girl with recurred SAA 5 yr after IST who underwent unrelated donor CBT after a modified regimen. This patient had renal and cardiac dysfunction, and lacked suitable bone marrow donors. The 3.9 × 107/kg CB cells from an HLA one-locus mismatched unrelated donor were infused after conditioning with total body irradiation (5 Gy), melphalan (120 mg/m2), and fludarabin (120 mg/m2). Hematological recovery was favorable in complete chimerism. A major complication was only skin graft-versus-host disease (grade I). CB could be an alternate stem cell source for childhood SAA after modified preparative regimen.
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U2 - 10.1111/j.1399-3046.2006.00486.x
DO - 10.1111/j.1399-3046.2006.00486.x
M3 - Article
C2 - 16712610
AN - SCOPUS:33646887741
SN - 1397-3142
VL - 10
SP - 497
EP - 500
JO - Pediatric Transplantation
JF - Pediatric Transplantation
IS - 4
ER -
