Unsymmetric indolylmaleimides: Synthesis, photophysical properties and amyloid detection

Manabu Nakazono, Konen Obayashi, Yuji Oshikawa, Kazushi Tani, Genki Suenaga, Yukio Ando, Shinkoh Nanbu, Ryoichi Kuwano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Various unsymmetric indolylmaleimides were synthesized. Their photophysical properties and affinities for amyloid fibrils were evaluated. Some unsymmetric indolylmaleimides have large Stokes shifts of more than 120 nm, fluorescence emission maxima wavelengths of more than 550 nm and different emissions under UV irradiation at 365 nm. From the results of histopathologic methods using stains, 3-(1H-indol-3-yl)-1-methyl-4-phenyl-1H-pyrrole-2,5-dione has high selectivity for amyloid fibrils in senile systemic amyloidosis.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume289
DOIs
Publication statusPublished - Sep 1 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

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