TY - JOUR
T1 - Unsymmetric indolylmaleimides
T2 - Synthesis, photophysical properties and amyloid detection
AU - Nakazono, Manabu
AU - Obayashi, Konen
AU - Oshikawa, Yuji
AU - Tani, Kazushi
AU - Suenaga, Genki
AU - Ando, Yukio
AU - Nanbu, Shinkoh
AU - Kuwano, Ryoichi
N1 - Funding Information:
The authors thank the Japan Society for the Promotion of Science for their financial support (Grant No. 23590043 ). This work was performed under a Cooperative Research Program of the “Network Joint Research Center for Materials and Devices.”
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Various unsymmetric indolylmaleimides were synthesized. Their photophysical properties and affinities for amyloid fibrils were evaluated. Some unsymmetric indolylmaleimides have large Stokes shifts of more than 120 nm, fluorescence emission maxima wavelengths of more than 550 nm and different emissions under UV irradiation at 365 nm. From the results of histopathologic methods using stains, 3-(1H-indol-3-yl)-1-methyl-4-phenyl-1H-pyrrole-2,5-dione has high selectivity for amyloid fibrils in senile systemic amyloidosis.
AB - Various unsymmetric indolylmaleimides were synthesized. Their photophysical properties and affinities for amyloid fibrils were evaluated. Some unsymmetric indolylmaleimides have large Stokes shifts of more than 120 nm, fluorescence emission maxima wavelengths of more than 550 nm and different emissions under UV irradiation at 365 nm. From the results of histopathologic methods using stains, 3-(1H-indol-3-yl)-1-methyl-4-phenyl-1H-pyrrole-2,5-dione has high selectivity for amyloid fibrils in senile systemic amyloidosis.
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U2 - 10.1016/j.jphotochem.2014.04.027
DO - 10.1016/j.jphotochem.2014.04.027
M3 - Article
AN - SCOPUS:84902661022
SN - 1010-6030
VL - 289
SP - 39
EP - 46
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
ER -