TY - JOUR
T1 - Unusual multiple gastric carcinoids with hypergastrinemia
T2 - Report of a case
AU - Nakata, Kohei
AU - Aishima, Shinichi
AU - Ichimiya, Hitoshi
AU - Yao, Takashi
AU - Matsuura, Takashi
AU - Seo, Mitsuru
AU - Nagai, Eishi
AU - Okido, Masayuki
AU - Kato, Masato
AU - Nakagaki, Mitsuru
AU - Tsuneyoshi, Masazumi
AU - Tanaka, Masao
PY - 2010/3
Y1 - 2010/3
N2 - We report the case of a patient demonstrating multiple gastric carcinoids with hypergastrinemia. A 50-yearold Japanese woman was admitted to our hospital for the further examination of multiple carcinoids of the stomach with hypergastrinemia, although she was asymptomatic. However, based on our clinical examination, this case seemed to be neither type I nor II carcinoid. We performed a total gastrectomy with D1 lymph node dissection. A pathological examination showed numerous endocrine micronests, hyperplasia of the parietal cells extending to the foveolar neck region, and numerous dilated oxyntic glands fi lled with eosinophilic secretions. Many parietal cells exhibited vacuolated cytoplasms and apical snouts. Furthermore, the dilated glands at the base of the mucosa had hyperchromatic nuclei and ciliated surfaces. The postoperative serum gastrin level was soon normalized to 47 pg/ml. This is only the third reported case of multiple gastric carcinoids with hypergastrinemia due to an intrinsic abnormality in the acid secretion of the parietal cells.
AB - We report the case of a patient demonstrating multiple gastric carcinoids with hypergastrinemia. A 50-yearold Japanese woman was admitted to our hospital for the further examination of multiple carcinoids of the stomach with hypergastrinemia, although she was asymptomatic. However, based on our clinical examination, this case seemed to be neither type I nor II carcinoid. We performed a total gastrectomy with D1 lymph node dissection. A pathological examination showed numerous endocrine micronests, hyperplasia of the parietal cells extending to the foveolar neck region, and numerous dilated oxyntic glands fi lled with eosinophilic secretions. Many parietal cells exhibited vacuolated cytoplasms and apical snouts. Furthermore, the dilated glands at the base of the mucosa had hyperchromatic nuclei and ciliated surfaces. The postoperative serum gastrin level was soon normalized to 47 pg/ml. This is only the third reported case of multiple gastric carcinoids with hypergastrinemia due to an intrinsic abnormality in the acid secretion of the parietal cells.
UR - http://www.scopus.com/inward/record.url?scp=77952317285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952317285&partnerID=8YFLogxK
U2 - 10.1007/s00595-009-4032-7
DO - 10.1007/s00595-009-4032-7
M3 - Article
C2 - 20180083
AN - SCOPUS:77952317285
VL - 40
SP - 267
EP - 271
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 3
ER -