Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes

Masakazu Takahara, Kazuyo Kita, Konosuke Nagae, Akiko Hachiya, Ran Hidaka, Tomoyo Isotani, Kazuko Doi, Kenjiro Takei, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

Bidens pilosa extract has an antioxidative effect and has recently been used for the treatment of livedo vasculopathy as a folk medicine. We investigated the effects of Bidens pilosa extract on human cultured keratinocytes. Bidens pilosa extract induced nuclear translocation of aryl hydrocarbon receptor from cytoplasm. The AhR activation up-regulated anti-oxidative signaling pathways such as nuclear factor-erythroid-2-related factor-2 and NAD(P)H: quinone oxidoreductase 1. These findings may explain, at least in part, the anti-oxidative mechanism of Bidens pilosa extract.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalNishinihon Journal of Dermatology
Volume75
Issue number3
DOIs
Publication statusPublished - Aug 29 2013

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Keratinocytes
Up-Regulation
Aryl Hydrocarbon Receptors
Traditional Medicine
NAD
Oxidoreductases
Cytoplasm
Bidens pilosa plant extract
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes. / Takahara, Masakazu; Kita, Kazuyo; Nagae, Konosuke; Hachiya, Akiko; Hidaka, Ran; Isotani, Tomoyo; Doi, Kazuko; Takei, Kenjiro; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 75, No. 3, 29.08.2013, p. 230-233.

Research output: Contribution to journalArticle

Takahara, M, Kita, K, Nagae, K, Hachiya, A, Hidaka, R, Isotani, T, Doi, K, Takei, K & Furue, M 2013, 'Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes', Nishinihon Journal of Dermatology, vol. 75, no. 3, pp. 230-233. https://doi.org/10.2336/nishinihonhifu.75.230
Takahara, Masakazu ; Kita, Kazuyo ; Nagae, Konosuke ; Hachiya, Akiko ; Hidaka, Ran ; Isotani, Tomoyo ; Doi, Kazuko ; Takei, Kenjiro ; Furue, Masutaka. / Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes. In: Nishinihon Journal of Dermatology. 2013 ; Vol. 75, No. 3. pp. 230-233.
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