Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes

Masakazu Takahara; Kazuyo Kita; Konosuke Nagae; Akiko Hachiya; Ran Hidaka; Tomoyo Isotani; Kazuko Doi; Kenjiro Takei; Masutaka Furue

doi:10.2336/nishinihonhifu.75.230

Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes

Masakazu Takahara, Kazuyo Kita, Konosuke Nagae, Akiko Hachiya, Ran Hidaka, Tomoyo Isotani, Kazuko Doi, Kenjiro Takei, Masutaka Furue

Research output: Contribution to journal › Article › peer-review

Abstract

Bidens pilosa extract has an antioxidative effect and has recently been used for the treatment of livedo vasculopathy as a folk medicine. We investigated the effects of Bidens pilosa extract on human cultured keratinocytes. Bidens pilosa extract induced nuclear translocation of aryl hydrocarbon receptor from cytoplasm. The AhR activation up-regulated anti-oxidative signaling pathways such as nuclear factor-erythroid-2-related factor-2 and NAD(P)H: quinone oxidoreductase 1. These findings may explain, at least in part, the anti-oxidative mechanism of Bidens pilosa extract.

Original language	English
Pages (from-to)	230-233
Number of pages	4
Journal	Nishinihon Journal of Dermatology
Volume	75
Issue number	3
DOIs	https://doi.org/10.2336/nishinihonhifu.75.230
Publication status	Published - 2013

All Science Journal Classification (ASJC) codes

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2336/nishinihonhifu.75.230

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abstract = "Bidens pilosa extract has an antioxidative effect and has recently been used for the treatment of livedo vasculopathy as a folk medicine. We investigated the effects of Bidens pilosa extract on human cultured keratinocytes. Bidens pilosa extract induced nuclear translocation of aryl hydrocarbon receptor from cytoplasm. The AhR activation up-regulated anti-oxidative signaling pathways such as nuclear factor-erythroid-2-related factor-2 and NAD(P)H: quinone oxidoreductase 1. These findings may explain, at least in part, the anti-oxidative mechanism of Bidens pilosa extract.",

author = "Masakazu Takahara and Kazuyo Kita and Konosuke Nagae and Akiko Hachiya and Ran Hidaka and Tomoyo Isotani and Kazuko Doi and Kenjiro Takei and Masutaka Furue",

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T1 - Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes

AU - Takahara, Masakazu

AU - Kita, Kazuyo

AU - Nagae, Konosuke

AU - Hachiya, Akiko

AU - Hidaka, Ran

AU - Isotani, Tomoyo

AU - Doi, Kazuko

AU - Takei, Kenjiro

AU - Furue, Masutaka

PY - 2013

Y1 - 2013

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AB - Bidens pilosa extract has an antioxidative effect and has recently been used for the treatment of livedo vasculopathy as a folk medicine. We investigated the effects of Bidens pilosa extract on human cultured keratinocytes. Bidens pilosa extract induced nuclear translocation of aryl hydrocarbon receptor from cytoplasm. The AhR activation up-regulated anti-oxidative signaling pathways such as nuclear factor-erythroid-2-related factor-2 and NAD(P)H: quinone oxidoreductase 1. These findings may explain, at least in part, the anti-oxidative mechanism of Bidens pilosa extract.

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Up-regulation of Nrf-2 and nqo1 expression by bidens pilosa extract in human keratinocytes

Abstract

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