Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications

Hak Lae Lee, Jung Hwan Park, Hyun Seok Choe, Myung Soo Lee, Jeong Min Park, Naoyuki Harada, Yoichi Sasaki, Nobuhiro Yanai, Nobuo Kimizuka, Jintao Zhu, Suk Ho Bhang, Jae Hyuk Kim

Research output: Contribution to journalArticle

Abstract

A recyclable, aqueous phase functioning and biocompatible photon upconverting system is developed. Hollow mesoporous silica microcapsules (HMSMs) with ordered radial mesochannels were employed, for the first time, as vehicles for the post-encapsulation of oil phase triplet-triplet annihilation upconversion (TTA-UC), with the capability of homogeneous suspension in water. In-depth characterization of such upconverting oil-laden HMSMs (UC-HMSMs) showed that the mesoporous silica shells reversibly stabilized the encapsulated UC oil in water to allow efficient upconverted emission, even under aerated conditions. In addition, the UC-HMSMs were found to actively bind to the surface of human mesenchymal stem cells without significant cytotoxicity and displayed upconverted bright blue emission under 640 nm excitation, indicating a potential of our new TTA-UC system in biophotonic applications. These findings reveal the great promise of UC-HMSMs to serve as ideal vehicles not only for ultralow-power in vivo imaging but also for stem cell labeling, to facilitate the tracking of tumor cells in animal models.

Original languageEnglish
Pages (from-to)26571-26580
Number of pages10
JournalACS Applied Materials and Interfaces
Volume11
Issue number30
DOIs
Publication statusPublished - Jul 31 2019

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Silicon Dioxide
Capsules
Oils
Silica
Stem cells
Water
Cytotoxicity
Encapsulation
Labeling
Tumors
Suspensions
Animals
Photons
Cells
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Lee, H. L., Park, J. H., Choe, H. S., Lee, M. S., Park, J. M., Harada, N., ... Kim, J. H. (2019). Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications. ACS Applied Materials and Interfaces, 11(30), 26571-26580. https://doi.org/10.1021/acsami.9b06620

Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications. / Lee, Hak Lae; Park, Jung Hwan; Choe, Hyun Seok; Lee, Myung Soo; Park, Jeong Min; Harada, Naoyuki; Sasaki, Yoichi; Yanai, Nobuhiro; Kimizuka, Nobuo; Zhu, Jintao; Bhang, Suk Ho; Kim, Jae Hyuk.

In: ACS Applied Materials and Interfaces, Vol. 11, No. 30, 31.07.2019, p. 26571-26580.

Research output: Contribution to journalArticle

Lee, HL, Park, JH, Choe, HS, Lee, MS, Park, JM, Harada, N, Sasaki, Y, Yanai, N, Kimizuka, N, Zhu, J, Bhang, SH & Kim, JH 2019, 'Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications', ACS Applied Materials and Interfaces, vol. 11, no. 30, pp. 26571-26580. https://doi.org/10.1021/acsami.9b06620
Lee, Hak Lae ; Park, Jung Hwan ; Choe, Hyun Seok ; Lee, Myung Soo ; Park, Jeong Min ; Harada, Naoyuki ; Sasaki, Yoichi ; Yanai, Nobuhiro ; Kimizuka, Nobuo ; Zhu, Jintao ; Bhang, Suk Ho ; Kim, Jae Hyuk. / Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications. In: ACS Applied Materials and Interfaces. 2019 ; Vol. 11, No. 30. pp. 26571-26580.
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