Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications

Hak Lae Lee, Jung Hwan Park, Hyun Seok Choe, Myung Soo Lee, Jeong Min Park, Naoyuki Harada, Yoichi Sasaki, Nobuhiro Yanai, Nobuo Kimizuka, Jintao Zhu, Suk Ho Bhang, Jae Hyuk Kim

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    A recyclable, aqueous phase functioning and biocompatible photon upconverting system is developed. Hollow mesoporous silica microcapsules (HMSMs) with ordered radial mesochannels were employed, for the first time, as vehicles for the post-encapsulation of oil phase triplet-triplet annihilation upconversion (TTA-UC), with the capability of homogeneous suspension in water. In-depth characterization of such upconverting oil-laden HMSMs (UC-HMSMs) showed that the mesoporous silica shells reversibly stabilized the encapsulated UC oil in water to allow efficient upconverted emission, even under aerated conditions. In addition, the UC-HMSMs were found to actively bind to the surface of human mesenchymal stem cells without significant cytotoxicity and displayed upconverted bright blue emission under 640 nm excitation, indicating a potential of our new TTA-UC system in biophotonic applications. These findings reveal the great promise of UC-HMSMs to serve as ideal vehicles not only for ultralow-power in vivo imaging but also for stem cell labeling, to facilitate the tracking of tumor cells in animal models.

    Original languageEnglish
    Pages (from-to)26571-26580
    Number of pages10
    JournalACS Applied Materials and Interfaces
    Issue number30
    Publication statusPublished - Jul 31 2019

    All Science Journal Classification (ASJC) codes

    • Materials Science(all)


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