Upregulation of FLG, LOR, and IVL expression by rhodiola crenulata root extract via aryl hydrocarbon receptor

Differential involvement of OVOL1

Akiko Hashimoto-Hachiya, Gaku Tsuji, Mika Murai, Xianghong Yan, Masutaka Furue

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion. However, RCE-mediated IVL upregulation was AHR-dependent but OVOL1-independent. Coordinated upregulation of skin barrier proteins by RCE via AHR may be beneficial in the management of barrier-disrupted inflammatory skin diseases such as atopic dermatitis.

Original languageEnglish
Article number1654
JournalInternational journal of molecular sciences
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 4 2018

Fingerprint

Rhodiola
Aryl Hydrocarbon Receptors
Up-Regulation
hydrocarbons
Hydrocarbons
Skin
dermatitis
proteins
Proteins
Oxidative stress
Phytochemicals
Atopic Dermatitis
Keratinocytes
Skin Diseases
Radiation
Oxidative Stress
involucrin
filaggrin
loricrin
radiation

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Upregulation of FLG, LOR, and IVL expression by rhodiola crenulata root extract via aryl hydrocarbon receptor : Differential involvement of OVOL1. / Hashimoto-Hachiya, Akiko; Tsuji, Gaku; Murai, Mika; Yan, Xianghong; Furue, Masutaka.

In: International journal of molecular sciences, Vol. 19, No. 6, 1654, 04.06.2018.

Research output: Contribution to journalArticle

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AU - Murai, Mika

AU - Yan, Xianghong

AU - Furue, Masutaka

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