Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis: Positive correlation with disease severity

Motozumi Minohara, Takeshi Matsuoka, Wei Li, Manabu Osoegawa, Takaaki Ishizu, Yasumasa Ohyagi, Jun-Ichi Kira

Research output: Contribution to journalArticle

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Abstract

To clarify the role of myeloperoxidase (MPO) in multiple sclerosis (MS), we measured serum MPO levels in 86 Japanese patients with relapsing remitting MS, 47 with opticospinal MS (OSMS) and 39 with conventional MS (CMS), and 85 healthy subjects by sandwich enzyme immunoassays and analyzed relationships with clinical features. We found a significant increase in serum MPO in OSMS patients at relapse and remission, and in CMS patients at remission compared with controls. By logistic regression analysis, the clinical variable associated with high level of MPO at remission in OSMS patients (higher than the mean ± 2 S.D. of healthy controls) was only Kurtzke's Expanded Disability Status Scale (EDSS) score in blood sampling (p = 0.0245); that is, a greater EDSS scores in the high MPO group, whereas in CMS none were associated. The results of our study suggest that MPO levels in remission are related with severe tissue destruction in OSMS.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalJournal of Neuroimmunology
Volume178
Issue number1-2
DOIs
Publication statusPublished - Sep 1 2006
Externally publishedYes

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Peroxidase
Up-Regulation
Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Serum
Immunoenzyme Techniques
Opticospinal Multiple Sclerosis
Healthy Volunteers
Logistic Models
Regression Analysis
Recurrence

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis : Positive correlation with disease severity. / Minohara, Motozumi; Matsuoka, Takeshi; Li, Wei; Osoegawa, Manabu; Ishizu, Takaaki; Ohyagi, Yasumasa; Kira, Jun-Ichi.

In: Journal of Neuroimmunology, Vol. 178, No. 1-2, 01.09.2006, p. 156-160.

Research output: Contribution to journalArticle

Minohara, Motozumi ; Matsuoka, Takeshi ; Li, Wei ; Osoegawa, Manabu ; Ishizu, Takaaki ; Ohyagi, Yasumasa ; Kira, Jun-Ichi. / Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis : Positive correlation with disease severity. In: Journal of Neuroimmunology. 2006 ; Vol. 178, No. 1-2. pp. 156-160.
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