Upregulation of NMDA receptor subunit proteins in the cerebral cortex during diazepam withdrawal

Makoto Tsuda, Yoshihiko Chiba, Tsutomu Suzuki, Miwa Misawa

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The present study investigated the changes in NMDA receptor subunit proteins in diazepam-withdrawn rat cerebral cortex, using Western blotting analysis. The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats. Therefore, an increase in the NR1 and NR2B subunit proteins may be responsible for both the previously observed upregulation of [3H]dizocilpine binding in the cerebral cortex and the appearance of diazepam withdrawal signs.

Original languageEnglish
Pages (from-to)R1
JournalEuropean Journal of Pharmacology
Volume341
Issue number2-3
DOIs
Publication statusPublished - Jan 12 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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