Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma

Li Zhu, Takamichi Ito, Takeshi Nakahara, Konosuke Nagae, Yoko Fuyuno, Masayoshi Nakao, Maki Akahoshi, Rieko Nakagawa, Yating Tu, Uchi Hiroshi, Masutaka Furue

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

S100P is a member of the S100 family. Increased levels of S100P have been documented in various malignancies. Binding of extracellular S100P to receptor for advanced glycation end products (RAGE) or coupling of intracellular S100P with a cytoskeletal protein, ezrin, play a crucial role in tumor growth, invasion and metastasis. However, little is known about the expression of S100P, RAGE and ezrin in malignant melanoma. We immunostained these three molecules in 20 primary and 20 metastatic melanomas. Samples of 20 benign nevus pigmentosus and 10 of normal skin were tested as controls. The expression levels (percentage of positively stained cells) of S100P, RAGE and ezrin were significantly higher in melanomas than in nevus pigmentosus. Moreover, slightly but significantly higher expression levels were observed in metastatic than in primary melanomas. Significant positive correlations were evident between the expression levels of S100P and RAGE, S100P and ezrin, and RAGE and ezrin, respectively. In conclusion, the coordinate upregulation of S100P, RAGE and ezrin may possibly facilitate malignant transformation of melanoma.

Original languageEnglish
Pages (from-to)973-979
Number of pages7
JournalJournal of Dermatology
Volume40
Issue number12
DOIs
Publication statusPublished - Dec 1 2013

Fingerprint

Melanoma
Up-Regulation
Nevi and Melanomas
Cytoskeletal Proteins
Nevus
Advanced Glycosylation End Product-Specific Receptor
ezrin
Neoplasms
Neoplasm Metastasis
Skin
Growth

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma. / Zhu, Li; Ito, Takamichi; Nakahara, Takeshi; Nagae, Konosuke; Fuyuno, Yoko; Nakao, Masayoshi; Akahoshi, Maki; Nakagawa, Rieko; Tu, Yating; Hiroshi, Uchi; Furue, Masutaka.

In: Journal of Dermatology, Vol. 40, No. 12, 01.12.2013, p. 973-979.

Research output: Contribution to journalArticle

Zhu, Li ; Ito, Takamichi ; Nakahara, Takeshi ; Nagae, Konosuke ; Fuyuno, Yoko ; Nakao, Masayoshi ; Akahoshi, Maki ; Nakagawa, Rieko ; Tu, Yating ; Hiroshi, Uchi ; Furue, Masutaka. / Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma. In: Journal of Dermatology. 2013 ; Vol. 40, No. 12. pp. 973-979.
@article{098b87af87564ce397469cf44bb695f8,
title = "Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma",
abstract = "S100P is a member of the S100 family. Increased levels of S100P have been documented in various malignancies. Binding of extracellular S100P to receptor for advanced glycation end products (RAGE) or coupling of intracellular S100P with a cytoskeletal protein, ezrin, play a crucial role in tumor growth, invasion and metastasis. However, little is known about the expression of S100P, RAGE and ezrin in malignant melanoma. We immunostained these three molecules in 20 primary and 20 metastatic melanomas. Samples of 20 benign nevus pigmentosus and 10 of normal skin were tested as controls. The expression levels (percentage of positively stained cells) of S100P, RAGE and ezrin were significantly higher in melanomas than in nevus pigmentosus. Moreover, slightly but significantly higher expression levels were observed in metastatic than in primary melanomas. Significant positive correlations were evident between the expression levels of S100P and RAGE, S100P and ezrin, and RAGE and ezrin, respectively. In conclusion, the coordinate upregulation of S100P, RAGE and ezrin may possibly facilitate malignant transformation of melanoma.",
author = "Li Zhu and Takamichi Ito and Takeshi Nakahara and Konosuke Nagae and Yoko Fuyuno and Masayoshi Nakao and Maki Akahoshi and Rieko Nakagawa and Yating Tu and Uchi Hiroshi and Masutaka Furue",
year = "2013",
month = "12",
day = "1",
doi = "10.1111/1346-8138.12323",
language = "English",
volume = "40",
pages = "973--979",
journal = "Journal of Dermatology",
issn = "0385-2407",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma

AU - Zhu, Li

AU - Ito, Takamichi

AU - Nakahara, Takeshi

AU - Nagae, Konosuke

AU - Fuyuno, Yoko

AU - Nakao, Masayoshi

AU - Akahoshi, Maki

AU - Nakagawa, Rieko

AU - Tu, Yating

AU - Hiroshi, Uchi

AU - Furue, Masutaka

PY - 2013/12/1

Y1 - 2013/12/1

N2 - S100P is a member of the S100 family. Increased levels of S100P have been documented in various malignancies. Binding of extracellular S100P to receptor for advanced glycation end products (RAGE) or coupling of intracellular S100P with a cytoskeletal protein, ezrin, play a crucial role in tumor growth, invasion and metastasis. However, little is known about the expression of S100P, RAGE and ezrin in malignant melanoma. We immunostained these three molecules in 20 primary and 20 metastatic melanomas. Samples of 20 benign nevus pigmentosus and 10 of normal skin were tested as controls. The expression levels (percentage of positively stained cells) of S100P, RAGE and ezrin were significantly higher in melanomas than in nevus pigmentosus. Moreover, slightly but significantly higher expression levels were observed in metastatic than in primary melanomas. Significant positive correlations were evident between the expression levels of S100P and RAGE, S100P and ezrin, and RAGE and ezrin, respectively. In conclusion, the coordinate upregulation of S100P, RAGE and ezrin may possibly facilitate malignant transformation of melanoma.

AB - S100P is a member of the S100 family. Increased levels of S100P have been documented in various malignancies. Binding of extracellular S100P to receptor for advanced glycation end products (RAGE) or coupling of intracellular S100P with a cytoskeletal protein, ezrin, play a crucial role in tumor growth, invasion and metastasis. However, little is known about the expression of S100P, RAGE and ezrin in malignant melanoma. We immunostained these three molecules in 20 primary and 20 metastatic melanomas. Samples of 20 benign nevus pigmentosus and 10 of normal skin were tested as controls. The expression levels (percentage of positively stained cells) of S100P, RAGE and ezrin were significantly higher in melanomas than in nevus pigmentosus. Moreover, slightly but significantly higher expression levels were observed in metastatic than in primary melanomas. Significant positive correlations were evident between the expression levels of S100P and RAGE, S100P and ezrin, and RAGE and ezrin, respectively. In conclusion, the coordinate upregulation of S100P, RAGE and ezrin may possibly facilitate malignant transformation of melanoma.

UR - http://www.scopus.com/inward/record.url?scp=84890425750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890425750&partnerID=8YFLogxK

U2 - 10.1111/1346-8138.12323

DO - 10.1111/1346-8138.12323

M3 - Article

C2 - 24303922

AN - SCOPUS:84890425750

VL - 40

SP - 973

EP - 979

JO - Journal of Dermatology

JF - Journal of Dermatology

SN - 0385-2407

IS - 12

ER -