TY - JOUR
T1 - Urine diacetylspermine as a novel tumour maker for pancreatobiliary carcinomas
AU - Yamaguchi, K.
AU - Nakamura, M.
AU - Shirahane, K.
AU - Konomi, H.
AU - Torata, N.
AU - Hamasaki, N.
AU - Kawakita, M.
AU - Tanaka, M.
N1 - Funding Information:
This study is partially supported by grant from Fukuoka Industry, Science and Technology Foundation, Fukuoka, Japan, 2002 and 2003.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/3
Y1 - 2005/3
N2 - Background. Serum carcinoembryonic antigen (highly specific) and carbohydrate antigen 19-9 (highly sensitive) have been used as tumour markers for pancreatobiliary caners. A novel urine tumour marker, diacetylspermine, was compared with the two conventional serum tumour markers in 125 patients with pancreatobiliary diseases. Results. When the diagnosis of benign or malignant condition was examined, the sensitivity of urine diacetylspermine (75%) was higher than that of serum carcinoembryonic antigen (44%; P = 0.048) and the same as that of serum carbohydrate antigen 19-9 (75%). The specificity of urine diacetylspermine (81%) was lower than that of serum CEA (92%) and as high as that of serum carbohydrate antigen 19-9 (80%). The efficiency of urine diacetylspermine (79%) was higher than that of serum carcinoembryonic antigen (74%) and the same as that of serum carbohydrate antigen 19-9 (79%). Conclusion. These results suggest that urine diacetylspermine is a marker for pancreatobiliary carcinoma, which is as highly sensitive and specific as serum carbohydrate antigen 19-9.
AB - Background. Serum carcinoembryonic antigen (highly specific) and carbohydrate antigen 19-9 (highly sensitive) have been used as tumour markers for pancreatobiliary caners. A novel urine tumour marker, diacetylspermine, was compared with the two conventional serum tumour markers in 125 patients with pancreatobiliary diseases. Results. When the diagnosis of benign or malignant condition was examined, the sensitivity of urine diacetylspermine (75%) was higher than that of serum carcinoembryonic antigen (44%; P = 0.048) and the same as that of serum carbohydrate antigen 19-9 (75%). The specificity of urine diacetylspermine (81%) was lower than that of serum CEA (92%) and as high as that of serum carbohydrate antigen 19-9 (80%). The efficiency of urine diacetylspermine (79%) was higher than that of serum carcinoembryonic antigen (74%) and the same as that of serum carbohydrate antigen 19-9 (79%). Conclusion. These results suggest that urine diacetylspermine is a marker for pancreatobiliary carcinoma, which is as highly sensitive and specific as serum carbohydrate antigen 19-9.
UR - http://www.scopus.com/inward/record.url?scp=22844446525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22844446525&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2004.10.006
DO - 10.1016/j.dld.2004.10.006
M3 - Article
C2 - 15888284
AN - SCOPUS:22844446525
SN - 1590-8658
VL - 37
SP - 190
EP - 194
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 3
ER -