Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1

Shinji Yamamoto, Chiaki Sakemoto, Kensuke Iwasa, Kei Maruyama, Kuniyoshi Shimizu, Keisuke Yoshikawa

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. A pentacyclic triterpenoid compound, ursolic acid (UA), has various pharmacological activities, such as anti-inflammatory, anti-oxidative, and anti-apoptotic effects. In the present study, we investigated the effects of UA on cuprizone-induced demyelination, which is a model of MS. Oral administration of UA effectively suppressed cuprizone-induced demyelination and motor dysfunction via the enhancement of IGF-1 levels in the demyelinating lesions. Our results suggest that UA might be therapeutically useful for demyelination in MS.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalJournal of Pharmacological Sciences
Volume144
Issue number3
DOIs
Publication statusPublished - Nov 2020

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1'. Together they form a unique fingerprint.

Cite this