TY - JOUR
T1 - Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
AU - Yamamoto, Shinji
AU - Sakemoto, Chiaki
AU - Iwasa, Kensuke
AU - Maruyama, Kei
AU - Shimizu, Kuniyoshi
AU - Yoshikawa, Keisuke
N1 - Funding Information:
We thank the Division of Laboratory Animal Medicine, Biomedical Research Center, Saitama Medical University, for maintaining the mice. The authors thank Kumiko Komatsu (Division of Morphological Science, Biomedical Research Center, Saitama Medical University), for kind technical advice. We thank Nonoka Takeda, Mika Miura, and Mizuki Sakurai for research support. This research was supported by MEXT KAKENHI Grant number 18H06111, 19K21229, 18K06899, and 25870677, Ochiai Memorial Award Research Grant, Special Foundation Takeshi Nagao Research Grants Fund, Maruki Memorial Award, and Saitama Medical University internal grant (17-B-1-23, 19-A-1-01).
Funding Information:
We thank the Division of Laboratory Animal Medicine, Biomedical Research Center, Saitama Medical University, for maintaining the mice. The authors thank Kumiko Komatsu (Division of Morphological Science, Biomedical Research Center, Saitama Medical University), for kind technical advice. We thank Nonoka Takeda, Mika Miura, and Mizuki Sakurai for research support. This research was supported by MEXT KAKENHI Grant number 18H06111 , 19K21229 , 18K06899 , and 25870677 , Ochiai Memorial Award Research Grant , Special Foundation Takeshi Nagao Research Grants Fund, Maruki Memorial Award, and Saitama Medical University internal grant ( 17-B-1-23, 19-A-1-01 ).
Publisher Copyright:
© 2020 The Authors
PY - 2020/11
Y1 - 2020/11
N2 - Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. A pentacyclic triterpenoid compound, ursolic acid (UA), has various pharmacological activities, such as anti-inflammatory, anti-oxidative, and anti-apoptotic effects. In the present study, we investigated the effects of UA on cuprizone-induced demyelination, which is a model of MS. Oral administration of UA effectively suppressed cuprizone-induced demyelination and motor dysfunction via the enhancement of IGF-1 levels in the demyelinating lesions. Our results suggest that UA might be therapeutically useful for demyelination in MS.
AB - Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. A pentacyclic triterpenoid compound, ursolic acid (UA), has various pharmacological activities, such as anti-inflammatory, anti-oxidative, and anti-apoptotic effects. In the present study, we investigated the effects of UA on cuprizone-induced demyelination, which is a model of MS. Oral administration of UA effectively suppressed cuprizone-induced demyelination and motor dysfunction via the enhancement of IGF-1 levels in the demyelinating lesions. Our results suggest that UA might be therapeutically useful for demyelination in MS.
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U2 - 10.1016/j.jphs.2020.08.002
DO - 10.1016/j.jphs.2020.08.002
M3 - Article
C2 - 32921392
AN - SCOPUS:85089912801
SN - 1347-8613
VL - 144
SP - 119
EP - 122
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 3
ER -