Use of 13C-labeled glucose for measuring exogenous glucose oxidation in mice

Kengo Ishihara, Shinichi Oyaizu, Wataru Mizunoya, Yoshiko Fukuchi, Kyoden Yasumoto, Tohru Fushiki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The author modified a respiratory gas analyzer to analyze the respiratory 13CO2 of 12 small laboratory animals all at once. To investigate the practical use of this system, mice were orally (OR) or intravenously (IV) given glucose solutions containing three different amounts of 13C-labeled glucose. Expired 13CO2 derived from exogenous glucose was detected within 10 minutes after administration in OR mice, but about 30 minutes in IV mice. The height of the peak of 13CO2 expiration was correlated with the administered 13C-glucose mass.

Original languageEnglish
Pages (from-to)426-429
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Ishihara, K., Oyaizu, S., Mizunoya, W., Fukuchi, Y., Yasumoto, K., & Fushiki, T. (2002). Use of 13C-labeled glucose for measuring exogenous glucose oxidation in mice. Bioscience, Biotechnology and Biochemistry, 66(2), 426-429. https://doi.org/10.1271/bbb.66.426