Abstract
Introduction: This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma (BMI) on laboratory data and to determine the useful laboratory markers for diagnosing BMI. Methods: We compared laboratory data between patients with and without BMI. We performed multivariate logistic regression and receiver operating characteristic (ROC) analyses to evaluate the diagnostic values of independent predictors. Results: In the BMI group, platelets in peripheral blood (PLT) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non-BMI group (PLT, P <.0001; MgK, P =.0384). The rate of peripheral blood involvement by malignant lymphoma (PBI), red blood cell distribution width (RDW), D-dimer (DD), soluble interleukin-2 receptor (sIL2R), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) was significantly higher in the BMI group than in the non-BMI group (PBI, P <.0001; RDW, P =.0190; DD, P =.0006; sIL2R, P <.0001; AST, P =.0256; LDH, P =.0002). In multivariate analysis, PBI, PLT, sIL2R, and MgK levels were independent predictors of BMI. Conclusion: PBI, PLT, sIL2R, and MgK may be the useful laboratory markers for BMI diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 34-40 |
| Number of pages | 7 |
| Journal | International Journal of Laboratory Hematology |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 1 2018 |
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All Science Journal Classification (ASJC) codes
- Hematology
- Clinical Biochemistry
- Biochemistry, medical
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Useful laboratory markers for the diagnosis of bone marrow involvement by malignant lymphoma. / Nishimura, K.; Ota, R.; Mikajiri, Y.; Takahashi, K.; Sugishima, Setsuo; Eto, T.
In: International Journal of Laboratory Hematology, Vol. 40, No. 1, 01.02.2018, p. 34-40.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Useful laboratory markers for the diagnosis of bone marrow involvement by malignant lymphoma
AU - Nishimura, K.
AU - Ota, R.
AU - Mikajiri, Y.
AU - Takahashi, K.
AU - Sugishima, Setsuo
AU - Eto, T.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Introduction: This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma (BMI) on laboratory data and to determine the useful laboratory markers for diagnosing BMI. Methods: We compared laboratory data between patients with and without BMI. We performed multivariate logistic regression and receiver operating characteristic (ROC) analyses to evaluate the diagnostic values of independent predictors. Results: In the BMI group, platelets in peripheral blood (PLT) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non-BMI group (PLT, P <.0001; MgK, P =.0384). The rate of peripheral blood involvement by malignant lymphoma (PBI), red blood cell distribution width (RDW), D-dimer (DD), soluble interleukin-2 receptor (sIL2R), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) was significantly higher in the BMI group than in the non-BMI group (PBI, P <.0001; RDW, P =.0190; DD, P =.0006; sIL2R, P <.0001; AST, P =.0256; LDH, P =.0002). In multivariate analysis, PBI, PLT, sIL2R, and MgK levels were independent predictors of BMI. Conclusion: PBI, PLT, sIL2R, and MgK may be the useful laboratory markers for BMI diagnosis.
AB - Introduction: This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma (BMI) on laboratory data and to determine the useful laboratory markers for diagnosing BMI. Methods: We compared laboratory data between patients with and without BMI. We performed multivariate logistic regression and receiver operating characteristic (ROC) analyses to evaluate the diagnostic values of independent predictors. Results: In the BMI group, platelets in peripheral blood (PLT) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non-BMI group (PLT, P <.0001; MgK, P =.0384). The rate of peripheral blood involvement by malignant lymphoma (PBI), red blood cell distribution width (RDW), D-dimer (DD), soluble interleukin-2 receptor (sIL2R), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) was significantly higher in the BMI group than in the non-BMI group (PBI, P <.0001; RDW, P =.0190; DD, P =.0006; sIL2R, P <.0001; AST, P =.0256; LDH, P =.0002). In multivariate analysis, PBI, PLT, sIL2R, and MgK levels were independent predictors of BMI. Conclusion: PBI, PLT, sIL2R, and MgK may be the useful laboratory markers for BMI diagnosis.
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U2 - 10.1111/ijlh.12725
DO - 10.1111/ijlh.12725
M3 - Article
VL - 40
SP - 34
EP - 40
JO - International Journal of Laboratory Hematology
JF - International Journal of Laboratory Hematology
SN - 1751-5521
IS - 1
ER -