Useful laboratory markers for the diagnosis of bone marrow involvement by malignant lymphoma

Introduction: This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma (BMI) on laboratory data and to determine the useful laboratory markers for diagnosing BMI. Methods: We compared laboratory data between patients with and without BMI. We performed multivariate logistic regression and receiver operating characteristic (ROC) analyses to evaluate the diagnostic values of independent predictors. Results: In the BMI group, platelets in peripheral blood (PLT) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non-BMI group (PLT, P <.0001; MgK, P =.0384). The rate of peripheral blood involvement by malignant lymphoma (PBI), red blood cell distribution width (RDW), D-dimer (DD), soluble interleukin-2 receptor (sIL2R), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) was significantly higher in the BMI group than in the non-BMI group (PBI, P <.0001; RDW, P =.0190; DD, P =.0006; sIL2R, P <.0001; AST, P =.0256; LDH, P =.0002). In multivariate analysis, PBI, PLT, sIL2R, and MgK levels were independent predictors of BMI. Conclusion: PBI, PLT, sIL2R, and MgK may be the useful laboratory markers for BMI diagnosis.