Abstract
In neonate open-heart surgery, cardiopulmonary bypass (CPB) with extreme hemodilution induces an increased capillary permeability and accumulation of extravascular fluid, resulting in organ dysfunction. We evaluated the effects of a reduced priming volume for CPB and dilutional ultrafiltration (DUF) during neonatal open-heart surgery. Nineteen consecutive neonates with complete transposition of the great arteries who underwent an arterial switch operation were retrospectively assigned into two groups: the high-priming-volume circuit group (group A, n = 9) and the low-priming-volume circuit group (group B, n = 10). Patients in group B underwent surgery with a miniaturized CPB circuit and using the DUF technique. The priming volume of group B was nearly two-thirds that of group A. The water balance value after CPB and surgery was significantly lower in group B (-126 ± 118 ml, -116 ± 116 ml) than in group A (88 ± 218 ml, 83 ± 165 ml). Systolic blood pressure just after CPB was higher in group B (67.9 ± 9.1 mmHg) than in group A (55.4 ± 10.3 mmHg). Postoperative ventilatory support was shorter in group B (45 ± 19 h) than in group A (68 ± 27 h). In neonatal cardiac surgery, low-priming-volume CPB circuits and DUF improve the water balance during surgery and may attenuate any inflammatory reaction, which would help preserve postoperative organ function.
| Original language | English |
|---|---|
| Pages (from-to) | 9-12 |
| Number of pages | 4 |
| Journal | Journal of Artificial Organs |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 26 2004 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Biomaterials
- Biomedical Engineering
- Cardiology and Cardiovascular Medicine
Cite this
Usefullness of low-priming-volume cardiopulmonary bypass circuits and dilutional ultrafiltration in neonatal open-heart surgery. / Fukumura, Fumio; Kado, Hideaki; Imoto, Yutaka; Shiokawa, Yuichi; Minami, Kazu; Murakami, Jun; Yasui, Hisataka.
In: Journal of Artificial Organs, Vol. 7, No. 1, 26.04.2004, p. 9-12.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Usefullness of low-priming-volume cardiopulmonary bypass circuits and dilutional ultrafiltration in neonatal open-heart surgery
AU - Fukumura, Fumio
AU - Kado, Hideaki
AU - Imoto, Yutaka
AU - Shiokawa, Yuichi
AU - Minami, Kazu
AU - Murakami, Jun
AU - Yasui, Hisataka
PY - 2004/4/26
Y1 - 2004/4/26
N2 - In neonate open-heart surgery, cardiopulmonary bypass (CPB) with extreme hemodilution induces an increased capillary permeability and accumulation of extravascular fluid, resulting in organ dysfunction. We evaluated the effects of a reduced priming volume for CPB and dilutional ultrafiltration (DUF) during neonatal open-heart surgery. Nineteen consecutive neonates with complete transposition of the great arteries who underwent an arterial switch operation were retrospectively assigned into two groups: the high-priming-volume circuit group (group A, n = 9) and the low-priming-volume circuit group (group B, n = 10). Patients in group B underwent surgery with a miniaturized CPB circuit and using the DUF technique. The priming volume of group B was nearly two-thirds that of group A. The water balance value after CPB and surgery was significantly lower in group B (-126 ± 118 ml, -116 ± 116 ml) than in group A (88 ± 218 ml, 83 ± 165 ml). Systolic blood pressure just after CPB was higher in group B (67.9 ± 9.1 mmHg) than in group A (55.4 ± 10.3 mmHg). Postoperative ventilatory support was shorter in group B (45 ± 19 h) than in group A (68 ± 27 h). In neonatal cardiac surgery, low-priming-volume CPB circuits and DUF improve the water balance during surgery and may attenuate any inflammatory reaction, which would help preserve postoperative organ function.
AB - In neonate open-heart surgery, cardiopulmonary bypass (CPB) with extreme hemodilution induces an increased capillary permeability and accumulation of extravascular fluid, resulting in organ dysfunction. We evaluated the effects of a reduced priming volume for CPB and dilutional ultrafiltration (DUF) during neonatal open-heart surgery. Nineteen consecutive neonates with complete transposition of the great arteries who underwent an arterial switch operation were retrospectively assigned into two groups: the high-priming-volume circuit group (group A, n = 9) and the low-priming-volume circuit group (group B, n = 10). Patients in group B underwent surgery with a miniaturized CPB circuit and using the DUF technique. The priming volume of group B was nearly two-thirds that of group A. The water balance value after CPB and surgery was significantly lower in group B (-126 ± 118 ml, -116 ± 116 ml) than in group A (88 ± 218 ml, 83 ± 165 ml). Systolic blood pressure just after CPB was higher in group B (67.9 ± 9.1 mmHg) than in group A (55.4 ± 10.3 mmHg). Postoperative ventilatory support was shorter in group B (45 ± 19 h) than in group A (68 ± 27 h). In neonatal cardiac surgery, low-priming-volume CPB circuits and DUF improve the water balance during surgery and may attenuate any inflammatory reaction, which would help preserve postoperative organ function.
UR - http://www.scopus.com/inward/record.url?scp=1842686598&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842686598&partnerID=8YFLogxK
U2 - 10.1007/s10047-003-0241-9
DO - 10.1007/s10047-003-0241-9
M3 - Article
C2 - 15083338
AN - SCOPUS:1842686598
VL - 7
SP - 9
EP - 12
JO - Journal of Artificial Organs
JF - Journal of Artificial Organs
SN - 1434-7229
IS - 1
ER -