Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma: Correlation with stepwise histopathology

Kengo Yoshimitsu, Keijiro Kiyoshima, Hiroyuki Irie, Tsuyoshi Tajima, Yoshiki Asayama, Masakazu Hirakawa, Kousei Ishigami, Seiji Naito, Hiroshi Honda

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Abstract

Purpose: To elucidate the performance of apparent diffusion coefficient (ADC) map in localizing prostate carcinoma (PC) using stepwise histopathology as a reference. Materials and Methods: Preoperative MR images of 37 patients with PC who had undergone radical prostatectomy were retrospectively evaluated. First, T2-weighted images (T2WI) alone were interpreted (T2WI reading), and then T2WI along with ADC map were interpreted (T2WI/ ADC map reading). Sextant-based sensitivity and specificity, and the ratio of the detected volume to the whole tumor volume (% tumor volume) were compared between the two interpretations, and results were also correlated to Gleason's scores (GS). ADC values were correlated to histological grades. Results: Sensitivity was significantly higher in T2WI/ ADC map reading than in T2WI reading (71% vs. 51%), but specificity was similar (61% vs. 60%). By adding ADC map to T2WI, % tumor volume detected increased significantly in transitional zone (TZ) lesions, but not in peripheral zone (PZ) lesions. % tumor volume detected with T2WI/ADC map reading showed a positive correlation with GS of the specimens. Less differentiated PC were associated with lower ADC values and higher detectability. Conclusion: T2WI/ADC map reading was better than T2WI reading in PC detection and localization. This approach may be particularly useful for detecting TZ lesions and biologically aggressive lesions.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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Prostate
Reading
Carcinoma
Tumor Burden
Neoplasm Grading
Prostatectomy
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma : Correlation with stepwise histopathology. / Yoshimitsu, Kengo; Kiyoshima, Keijiro; Irie, Hiroyuki; Tajima, Tsuyoshi; Asayama, Yoshiki; Hirakawa, Masakazu; Ishigami, Kousei; Naito, Seiji; Honda, Hiroshi.

In: Journal of Magnetic Resonance Imaging, Vol. 27, No. 1, 01.01.2008, p. 132-139.

Research output: Contribution to journalArticle

Yoshimitsu, Kengo ; Kiyoshima, Keijiro ; Irie, Hiroyuki ; Tajima, Tsuyoshi ; Asayama, Yoshiki ; Hirakawa, Masakazu ; Ishigami, Kousei ; Naito, Seiji ; Honda, Hiroshi. / Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma : Correlation with stepwise histopathology. In: Journal of Magnetic Resonance Imaging. 2008 ; Vol. 27, No. 1. pp. 132-139.
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