Uterine artery embolization along with the administration of methotrexate for cervical ectopic pregnancy

Technical and clinical outcomes

Masakazu Hirakawa, Tsuyoshi Tajima, Kengo Yoshimitsu, Hiroyuki Irie, Kosei Ishigami, Hideaki Yahata, Norio Wake, Hiroshi Honda

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

OBJECTIVE. The objective of our study was to evaluate the technical and clinical outcomes of uterine artery embolization (UAE) along with the administration of methotrexate (MTX) for cervical ectopic pregnancy with vaginal bleeding as an alternative nonsurgical treatment to control bleeding and preserve fertility. MATERIALS AND METHODS. Eight patients (age range, 24-37 years; mean age, 30.1 years) with cervical ectopic pregnancy were treated with UAE using gelatin sponge particles to control vaginal bleeding. In seven patients, the administration of MTX was performed before, after, or before and after UAE. The follow-up periods after UAE ranged from 4 to 46 months (median, 8 months). We evaluated the UAE technique, clinical outcomes, complications, and fertility. RESULTS. In all patients, UAE could control active vaginal bleeding on gynecologic examination. In six patients, the cervical ectopic pregnancy was dramatically resolved. In the other two patients presenting with both fetal heartbeat before UAE and persistent high HCG levels, active vaginal rebleeding was observed. The rebleeding was successfully controlled by a second UAE procedure. No major complication related to UAE was detected. The uterus could be preserved in all patients. In seven patients, normal menses resumed within 2 months after UAE. In only one patient, amenorrhea continued 8 months after UAE. In all three patients who could be followed for 2 years or more, three had subsequent successful natural pregnancies, and two patients had live births. CONCLUSION. UAE along with the administration of MTX is effective in treating cervical ectopic pregnancy with vaginal bleeding while allowing the preservation of fertility.

Original languageEnglish
Pages (from-to)1601-1607
Number of pages7
JournalAmerican Journal of Roentgenology
Volume192
Issue number6
DOIs
Publication statusPublished - Jun 1 2009

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Uterine Artery Embolization
Ectopic Pregnancy
Methotrexate
Uterine Hemorrhage
Fertility
Fertility Preservation
Menstruation
Amenorrhea
Live Birth
Porifera
Gelatin
Uterus

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Uterine artery embolization along with the administration of methotrexate for cervical ectopic pregnancy : Technical and clinical outcomes. / Hirakawa, Masakazu; Tajima, Tsuyoshi; Yoshimitsu, Kengo; Irie, Hiroyuki; Ishigami, Kosei; Yahata, Hideaki; Wake, Norio; Honda, Hiroshi.

In: American Journal of Roentgenology, Vol. 192, No. 6, 01.06.2009, p. 1601-1607.

Research output: Contribution to journalArticle

Hirakawa, Masakazu ; Tajima, Tsuyoshi ; Yoshimitsu, Kengo ; Irie, Hiroyuki ; Ishigami, Kosei ; Yahata, Hideaki ; Wake, Norio ; Honda, Hiroshi. / Uterine artery embolization along with the administration of methotrexate for cervical ectopic pregnancy : Technical and clinical outcomes. In: American Journal of Roentgenology. 2009 ; Vol. 192, No. 6. pp. 1601-1607.
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