Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: Results from the Kyushu and Okinawa Population Study (KOPS)

N. Furusyo, T. Koga, M. Ai, S. Otokozawa, T. Kohzuma, H. Ikezaki, E. J. Schaefer, J. Hayashi

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Abstract

Aims/hypothesis: Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2-3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population. Methods: We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA 1c and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG ≥7.0 mmol/l or HbA 1c ≥6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively. Results: Glycated albumin levels were significantly correlated with HbA 1c levels (r=0.766, p<0.001) and FPG (r=0.706, p<0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0% and 15.9% (five of 276, 1.81%) than in those with glycated albumin <14% (three of 672, 0.45%) (p=0.037), and was markedly increased in those with a glycated albumin level >16% (58 of 207, 28.0%). Receiver operating characteristic curve analysis indicated that a glycated albumin level of ≥15.5% was optimal for predicting diabetes, with a sensitivity of 83.3% and a specificity of 83.3%. Conclusions/interpretation: There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.

Original languageEnglish
Pages (from-to)3028-3036
Number of pages9
JournalDiabetologia
Volume54
Issue number12
DOIs
Publication statusPublished - Dec 1 2011

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Diabetes Mellitus
Population
Glucose
Fasting
glycosylated serum albumin
ROC Curve
Type 2 Diabetes Mellitus
Reference Values
Health

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study : Results from the Kyushu and Okinawa Population Study (KOPS). / Furusyo, N.; Koga, T.; Ai, M.; Otokozawa, S.; Kohzuma, T.; Ikezaki, H.; Schaefer, E. J.; Hayashi, J.

In: Diabetologia, Vol. 54, No. 12, 01.12.2011, p. 3028-3036.

Research output: Contribution to journalArticle

Furusyo, N. ; Koga, T. ; Ai, M. ; Otokozawa, S. ; Kohzuma, T. ; Ikezaki, H. ; Schaefer, E. J. ; Hayashi, J. / Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study : Results from the Kyushu and Okinawa Population Study (KOPS). In: Diabetologia. 2011 ; Vol. 54, No. 12. pp. 3028-3036.
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abstract = "Aims/hypothesis: Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2-3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population. Methods: We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA 1c and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG ≥7.0 mmol/l or HbA 1c ≥6.5{\%} (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1{\%} and 1.6{\%}, respectively. Results: Glycated albumin levels were significantly correlated with HbA 1c levels (r=0.766, p<0.001) and FPG (r=0.706, p<0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0{\%} and 15.9{\%} (five of 276, 1.81{\%}) than in those with glycated albumin <14{\%} (three of 672, 0.45{\%}) (p=0.037), and was markedly increased in those with a glycated albumin level >16{\%} (58 of 207, 28.0{\%}). Receiver operating characteristic curve analysis indicated that a glycated albumin level of ≥15.5{\%} was optimal for predicting diabetes, with a sensitivity of 83.3{\%} and a specificity of 83.3{\%}. Conclusions/interpretation: There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.",
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T1 - Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study

T2 - Results from the Kyushu and Okinawa Population Study (KOPS)

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AU - Koga, T.

AU - Ai, M.

AU - Otokozawa, S.

AU - Kohzuma, T.

AU - Ikezaki, H.

AU - Schaefer, E. J.

AU - Hayashi, J.

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N2 - Aims/hypothesis: Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2-3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population. Methods: We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA 1c and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG ≥7.0 mmol/l or HbA 1c ≥6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively. Results: Glycated albumin levels were significantly correlated with HbA 1c levels (r=0.766, p<0.001) and FPG (r=0.706, p<0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0% and 15.9% (five of 276, 1.81%) than in those with glycated albumin <14% (three of 672, 0.45%) (p=0.037), and was markedly increased in those with a glycated albumin level >16% (58 of 207, 28.0%). Receiver operating characteristic curve analysis indicated that a glycated albumin level of ≥15.5% was optimal for predicting diabetes, with a sensitivity of 83.3% and a specificity of 83.3%. Conclusions/interpretation: There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.

AB - Aims/hypothesis: Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2-3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population. Methods: We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA 1c and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG ≥7.0 mmol/l or HbA 1c ≥6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively. Results: Glycated albumin levels were significantly correlated with HbA 1c levels (r=0.766, p<0.001) and FPG (r=0.706, p<0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0% and 15.9% (five of 276, 1.81%) than in those with glycated albumin <14% (three of 672, 0.45%) (p=0.037), and was markedly increased in those with a glycated albumin level >16% (58 of 207, 28.0%). Receiver operating characteristic curve analysis indicated that a glycated albumin level of ≥15.5% was optimal for predicting diabetes, with a sensitivity of 83.3% and a specificity of 83.3%. Conclusions/interpretation: There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.

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