Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma

Ako Hosono, Umio Yamaguchi, Atsushi Makimoto, Makoto Endo, Atsuko Watanabe, Tadakazu Shimoda, Mitsunori Kaya, Tadaki Matsumura, Hiroshi Sonobe, Tomomi Kusumi, Takehiko Yamaguchi, Tadashi Hasegawa

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14 Citations (Scopus)


Aims: To study the immunoexpression of cyclo-oxygenase (COX) 2 in osteoblastomas (OBs) and osteosarcomas (OSs), and to assess the utility of immunohistochemical analysis for COX 2 in the differential diagnosis of the two tumour forms. Methods: The immunohistochemical features of COX 2 were studied in 11 OBs and 30 OSs, including 26 high-grade OSs (16 osteoblastic, 7 chondroblastic, and 3 fibroblastic) and 4 low-grade OSs. Results: Tumour cells from all 11 OBs unequivocally showed diffuse, intense and cytoplasmic immunoreactivity for COX 2. Strong cytoplasmic expression of COX 2 was observed in 5 of 26 (19%) high-grade OSs, all chondroblastic. In one osteoblastic-type OS, COX 2 was expressed in the chondroblastic component, but this tumour was considered to be COX 2 negative. No COX 2 expression was noted in atypical osteoblastic cells. Staining in the four low-grade OSs was negative. Conclusion: The results of immunohistochemical analysis of COX 2 suggest that in addition to the routine histopathological evaluation, COX 2 is a valuable diagnostic marker in the distinction between OB and OS.

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalJournal of Clinical Pathology
Issue number4
Publication statusPublished - Apr 1 2007
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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