Utility of PDL progenitors for in vivo tissue regeneration

A report of 3 cases

F. Feng, K. Akiyama, Y. Liu, Takayoshi Yamaza, T. M. Wang, J. H. Chen, B. B. Wang, G. T.J. Huang, S. Wang, S. Shi

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Objective: Periodontal disease is an inflammatory disorder with widespread morbidities involving both oral and systemic health. The primary goal of periodontal treatment is the regeneration of the lost or diseased periodontium. In this study, we retrospectively examined feasibility and safety of reconstructing the periodontal intrabony defects with autologous periodontal ligament progenitor (PDLP) implantation in three patients. Materials and methods: In this retrospective pilot study, we treated 16 teeth with at least one deep intrabony defect of probing depth (PD) ≥ 6 mm with PDLP transplantation and evaluated clinical outcome measures in terms of probing depth, gingival recession and attachment gain for a duration of 32-72 months. Furthermore, we compare PDLPs with standard PDL stem cells (PDLSCs) and confirmed that PDLPs possessed progenitor characters. Results: Clinical examination indicated that transplantation of PDLPs may provide therapeutic benefit for the periodontal defects. All treated patients showed no adverse effects during the entire course of follow up. We also found that PDLPs were analogous to PDLSCs in terms of high proliferation, expression of mesenchymal surface molecules, multipotent differentiation, and in vivo tissue regain. However, PDLPs failed to express scleraxis, a marker of tendon, as seen in PDLSCs. Conclusions: This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis.

Original languageEnglish
Pages (from-to)20-28
Number of pages9
JournalOral Diseases
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

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Regeneration
Periodontal Ligament
Stem Cells
Transplantation
Gingival Recession
Safety
Periodontium
Periodontitis
Oral Health
Periodontal Diseases
Tendons
Tooth
Therapeutics
Retrospective Studies
Outcome Assessment (Health Care)
phenylalanyl-lysyl-phenylalanine
Morbidity

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Utility of PDL progenitors for in vivo tissue regeneration : A report of 3 cases. / Feng, F.; Akiyama, K.; Liu, Y.; Yamaza, Takayoshi; Wang, T. M.; Chen, J. H.; Wang, B. B.; Huang, G. T.J.; Wang, S.; Shi, S.

In: Oral Diseases, Vol. 16, No. 1, 01.01.2010, p. 20-28.

Research output: Contribution to journalArticle

Feng, F, Akiyama, K, Liu, Y, Yamaza, T, Wang, TM, Chen, JH, Wang, BB, Huang, GTJ, Wang, S & Shi, S 2010, 'Utility of PDL progenitors for in vivo tissue regeneration: A report of 3 cases', Oral Diseases, vol. 16, no. 1, pp. 20-28. https://doi.org/10.1111/j.1601-0825.2009.01593.x
Feng, F. ; Akiyama, K. ; Liu, Y. ; Yamaza, Takayoshi ; Wang, T. M. ; Chen, J. H. ; Wang, B. B. ; Huang, G. T.J. ; Wang, S. ; Shi, S. / Utility of PDL progenitors for in vivo tissue regeneration : A report of 3 cases. In: Oral Diseases. 2010 ; Vol. 16, No. 1. pp. 20-28.
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