Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung

Shigen Li, Kenji Kishihara, Nobuko Akashi, Hiromitsu Hara, Yasunobu Yoshikai, Yoichi Maekawa, Koji Yasutomo

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    The pulmonary resident T lymphocytes (RPLs) expressing a nearly invariant T cell receptor γδ heterodimer (γδTCR) migrate from fetal thymus to the lung epithlium, followed by RPL subsets expressing diverse sets of γδTCRs after birth. However, it remains unclear whether the fetal type Vγ6/Vδ1+ RPLs are essential for γδ T cell repertoire formation in the lung epithelium. In this study, we found a marked decrease in the number of γδRPLs at 4 weeks of age in Vδ1-/- mice and they predominantly expressed Vγ6 and Vδ4 genes. The skewed diversity towards the Vδ4-(Dδ1)-Dδ2-Jδ2 junctional region was observed only in γδ RPLs from 4-week-old Vδ1-/- mice, compared with those from 8-week-old Vδ1-/- mice and the both ages of wild-type mice. These results suggest that the invariant Vδ1+ T cells are crucial not only for optimal γδ T cell expansion but also for affecting the migration or microenvironment for other γδ T cells in the lung epithelium.

    Original languageEnglish
    Pages (from-to)246-251
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume365
    Issue number2
    DOIs
    Publication statusPublished - Jan 11 2008

    Fingerprint

    T-cells
    T-Lymphocytes
    Lung
    Epithelium
    Thymus
    T-Cell Antigen Receptor
    Thymus Gland
    Genes
    Parturition

    All Science Journal Classification (ASJC) codes

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Cite this

    Li, S., Kishihara, K., Akashi, N., Hara, H., Yoshikai, Y., Maekawa, Y., & Yasutomo, K. (2008). Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung. Biochemical and Biophysical Research Communications, 365(2), 246-251. https://doi.org/10.1016/j.bbrc.2007.10.163

    Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung. / Li, Shigen; Kishihara, Kenji; Akashi, Nobuko; Hara, Hiromitsu; Yoshikai, Yasunobu; Maekawa, Yoichi; Yasutomo, Koji.

    In: Biochemical and Biophysical Research Communications, Vol. 365, No. 2, 11.01.2008, p. 246-251.

    Research output: Contribution to journalArticle

    Li, S, Kishihara, K, Akashi, N, Hara, H, Yoshikai, Y, Maekawa, Y & Yasutomo, K 2008, 'Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung', Biochemical and Biophysical Research Communications, vol. 365, no. 2, pp. 246-251. https://doi.org/10.1016/j.bbrc.2007.10.163
    Li, Shigen ; Kishihara, Kenji ; Akashi, Nobuko ; Hara, Hiromitsu ; Yoshikai, Yasunobu ; Maekawa, Yoichi ; Yasutomo, Koji. / Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung. In: Biochemical and Biophysical Research Communications. 2008 ; Vol. 365, No. 2. pp. 246-251.
    @article{1a0678db2c3c4b77b7d1720b14c9f0fa,
    title = "Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung",
    abstract = "The pulmonary resident T lymphocytes (RPLs) expressing a nearly invariant T cell receptor γδ heterodimer (γδTCR) migrate from fetal thymus to the lung epithlium, followed by RPL subsets expressing diverse sets of γδTCRs after birth. However, it remains unclear whether the fetal type Vγ6/Vδ1+ RPLs are essential for γδ T cell repertoire formation in the lung epithelium. In this study, we found a marked decrease in the number of γδRPLs at 4 weeks of age in Vδ1-/- mice and they predominantly expressed Vγ6 and Vδ4 genes. The skewed diversity towards the Vδ4-(Dδ1)-Dδ2-Jδ2 junctional region was observed only in γδ RPLs from 4-week-old Vδ1-/- mice, compared with those from 8-week-old Vδ1-/- mice and the both ages of wild-type mice. These results suggest that the invariant Vδ1+ T cells are crucial not only for optimal γδ T cell expansion but also for affecting the migration or microenvironment for other γδ T cells in the lung epithelium.",
    author = "Shigen Li and Kenji Kishihara and Nobuko Akashi and Hiromitsu Hara and Yasunobu Yoshikai and Yoichi Maekawa and Koji Yasutomo",
    year = "2008",
    month = "1",
    day = "11",
    doi = "10.1016/j.bbrc.2007.10.163",
    language = "English",
    volume = "365",
    pages = "246--251",
    journal = "Biochemical and Biophysical Research Communications",
    issn = "0006-291X",
    publisher = "Academic Press Inc.",
    number = "2",

    }

    TY - JOUR

    T1 - Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung

    AU - Li, Shigen

    AU - Kishihara, Kenji

    AU - Akashi, Nobuko

    AU - Hara, Hiromitsu

    AU - Yoshikai, Yasunobu

    AU - Maekawa, Yoichi

    AU - Yasutomo, Koji

    PY - 2008/1/11

    Y1 - 2008/1/11

    N2 - The pulmonary resident T lymphocytes (RPLs) expressing a nearly invariant T cell receptor γδ heterodimer (γδTCR) migrate from fetal thymus to the lung epithlium, followed by RPL subsets expressing diverse sets of γδTCRs after birth. However, it remains unclear whether the fetal type Vγ6/Vδ1+ RPLs are essential for γδ T cell repertoire formation in the lung epithelium. In this study, we found a marked decrease in the number of γδRPLs at 4 weeks of age in Vδ1-/- mice and they predominantly expressed Vγ6 and Vδ4 genes. The skewed diversity towards the Vδ4-(Dδ1)-Dδ2-Jδ2 junctional region was observed only in γδ RPLs from 4-week-old Vδ1-/- mice, compared with those from 8-week-old Vδ1-/- mice and the both ages of wild-type mice. These results suggest that the invariant Vδ1+ T cells are crucial not only for optimal γδ T cell expansion but also for affecting the migration or microenvironment for other γδ T cells in the lung epithelium.

    AB - The pulmonary resident T lymphocytes (RPLs) expressing a nearly invariant T cell receptor γδ heterodimer (γδTCR) migrate from fetal thymus to the lung epithlium, followed by RPL subsets expressing diverse sets of γδTCRs after birth. However, it remains unclear whether the fetal type Vγ6/Vδ1+ RPLs are essential for γδ T cell repertoire formation in the lung epithelium. In this study, we found a marked decrease in the number of γδRPLs at 4 weeks of age in Vδ1-/- mice and they predominantly expressed Vγ6 and Vδ4 genes. The skewed diversity towards the Vδ4-(Dδ1)-Dδ2-Jδ2 junctional region was observed only in γδ RPLs from 4-week-old Vδ1-/- mice, compared with those from 8-week-old Vδ1-/- mice and the both ages of wild-type mice. These results suggest that the invariant Vδ1+ T cells are crucial not only for optimal γδ T cell expansion but also for affecting the migration or microenvironment for other γδ T cells in the lung epithelium.

    UR - http://www.scopus.com/inward/record.url?scp=36248970762&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=36248970762&partnerID=8YFLogxK

    U2 - 10.1016/j.bbrc.2007.10.163

    DO - 10.1016/j.bbrc.2007.10.163

    M3 - Article

    C2 - 17981152

    AN - SCOPUS:36248970762

    VL - 365

    SP - 246

    EP - 251

    JO - Biochemical and Biophysical Research Communications

    JF - Biochemical and Biophysical Research Communications

    SN - 0006-291X

    IS - 2

    ER -