TY - JOUR
T1 - Vδ1+ T cells are crucial for repertoire formation of γδ T cells in the lung
AU - Li, Shigen
AU - Kishihara, Kenji
AU - Akashi, Nobuko
AU - Hara, Hiromitsu
AU - Yoshikai, Yasunobu
AU - Maekawa, Yoichi
AU - Yasutomo, Koji
PY - 2008/1/11
Y1 - 2008/1/11
N2 - The pulmonary resident T lymphocytes (RPLs) expressing a nearly invariant T cell receptor γδ heterodimer (γδTCR) migrate from fetal thymus to the lung epithlium, followed by RPL subsets expressing diverse sets of γδTCRs after birth. However, it remains unclear whether the fetal type Vγ6/Vδ1+ RPLs are essential for γδ T cell repertoire formation in the lung epithelium. In this study, we found a marked decrease in the number of γδRPLs at 4 weeks of age in Vδ1-/- mice and they predominantly expressed Vγ6 and Vδ4 genes. The skewed diversity towards the Vδ4-(Dδ1)-Dδ2-Jδ2 junctional region was observed only in γδ RPLs from 4-week-old Vδ1-/- mice, compared with those from 8-week-old Vδ1-/- mice and the both ages of wild-type mice. These results suggest that the invariant Vδ1+ T cells are crucial not only for optimal γδ T cell expansion but also for affecting the migration or microenvironment for other γδ T cells in the lung epithelium.
AB - The pulmonary resident T lymphocytes (RPLs) expressing a nearly invariant T cell receptor γδ heterodimer (γδTCR) migrate from fetal thymus to the lung epithlium, followed by RPL subsets expressing diverse sets of γδTCRs after birth. However, it remains unclear whether the fetal type Vγ6/Vδ1+ RPLs are essential for γδ T cell repertoire formation in the lung epithelium. In this study, we found a marked decrease in the number of γδRPLs at 4 weeks of age in Vδ1-/- mice and they predominantly expressed Vγ6 and Vδ4 genes. The skewed diversity towards the Vδ4-(Dδ1)-Dδ2-Jδ2 junctional region was observed only in γδ RPLs from 4-week-old Vδ1-/- mice, compared with those from 8-week-old Vδ1-/- mice and the both ages of wild-type mice. These results suggest that the invariant Vδ1+ T cells are crucial not only for optimal γδ T cell expansion but also for affecting the migration or microenvironment for other γδ T cells in the lung epithelium.
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U2 - 10.1016/j.bbrc.2007.10.163
DO - 10.1016/j.bbrc.2007.10.163
M3 - Article
C2 - 17981152
AN - SCOPUS:36248970762
VL - 365
SP - 246
EP - 251
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -