V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze

Nobuaki Egashira, Akito Tanoue, Fuminori Higashihara, Kenichi Mishima, Yoshihiko Fukue, Yukio Takano, Gozoh Tsujimoto, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

In this study, we examined the performance of vasopressin V1a receptor (V1aR) and vasopressin V1b receptor (V1bR) knockout (KO) mice compared to wild-type (WT) mice in an eight-arm radial maze. V1aR KO mice exhibited an impairment of spatial memory in comparison to WT mice. By contrast, we did not observe any significant differences between the V1bR KO mice and the WT mice in the eight-arm radial maze. Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-arm radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalNeuroscience Letters
Volume356
Issue number3
DOIs
Publication statusPublished - Feb 19 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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