Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells

M. Maeda, S. Inaba, A. Nomura, Y. Tokunaga, Y. Sugio, Yoshikiyo Ito, T. Iino, T. Otsuka, S. Okamura, Y. Niho

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalLeukemia and Lymphoma
Volume39
Issue number3-4
DOIs
Publication statusPublished - Jan 1 2000

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Cryoglobulins
Cryoglobulinemia
Dendritic Cells
Vaccination
Monocytes
Neoplasm Antigens
Baths
Recurrence

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells. / Maeda, M.; Inaba, S.; Nomura, A.; Tokunaga, Y.; Sugio, Y.; Ito, Yoshikiyo; Iino, T.; Otsuka, T.; Okamura, S.; Niho, Y.

In: Leukemia and Lymphoma, Vol. 39, No. 3-4, 01.01.2000, p. 441-446.

Research output: Contribution to journalArticle

Maeda, M, Inaba, S, Nomura, A, Tokunaga, Y, Sugio, Y, Ito, Y, Iino, T, Otsuka, T, Okamura, S & Niho, Y 2000, 'Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells', Leukemia and Lymphoma, vol. 39, no. 3-4, pp. 441-446. https://doi.org/10.3109/10428190009065846
Maeda, M. ; Inaba, S. ; Nomura, A. ; Tokunaga, Y. ; Sugio, Y. ; Ito, Yoshikiyo ; Iino, T. ; Otsuka, T. ; Okamura, S. ; Niho, Y. / Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells. In: Leukemia and Lymphoma. 2000 ; Vol. 39, No. 3-4. pp. 441-446.
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