Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells

M. Maeda, S. Inaba, A. Nomura, Y. Tokunaga, Y. Sugio, Y. Itoh, T. Iino, T. Otsuka, S. Okamura, Y. Niho

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Abstract

We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalLeukemia and Lymphoma
Volume39
Issue number3-4
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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    Maeda, M., Inaba, S., Nomura, A., Tokunaga, Y., Sugio, Y., Itoh, Y., Iino, T., Otsuka, T., Okamura, S., & Niho, Y. (2000). Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells. Leukemia and Lymphoma, 39(3-4), 441-446. https://doi.org/10.3109/10428190009065846