Abstract
We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
| Original language | English |
|---|---|
| Pages (from-to) | 441-446 |
| Number of pages | 6 |
| Journal | Leukemia and Lymphoma |
| Volume | 39 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Jan 1 2000 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Hematology
- Oncology
- Cancer Research
Cite this
Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells. / Maeda, M.; Inaba, S.; Nomura, A.; Tokunaga, Y.; Sugio, Y.; Ito, Yoshikiyo; Iino, T.; Otsuka, T.; Okamura, S.; Niho, Y.
In: Leukemia and Lymphoma, Vol. 39, No. 3-4, 01.01.2000, p. 441-446.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells
AU - Maeda, M.
AU - Inaba, S.
AU - Nomura, A.
AU - Tokunaga, Y.
AU - Sugio, Y.
AU - Ito, Yoshikiyo
AU - Iino, T.
AU - Otsuka, T.
AU - Okamura, S.
AU - Niho, Y.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
AB - We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
UR - http://www.scopus.com/inward/record.url?scp=0034486840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034486840&partnerID=8YFLogxK
U2 - 10.3109/10428190009065846
DO - 10.3109/10428190009065846
M3 - Article
C2 - 11342327
AN - SCOPUS:0034486840
VL - 39
SP - 441
EP - 446
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 3-4
ER -