TY - JOUR
T1 - Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells
AU - Maeda, M.
AU - Inaba, S.
AU - Nomura, A.
AU - Tokunaga, Y.
AU - Sugio, Y.
AU - Itoh, Y.
AU - Iino, T.
AU - Otsuka, T.
AU - Okamura, S.
AU - Niho, Y.
N1 - Funding Information:
This work was supported by Grant-in-Aid No.0967 1 1 19 and a special budjet for high advanced clinical therapy from the Ministry of Education, Science and Culture of Japan. We are grateful to Y. Baba, Y. Matsuo and A. Saita for their valuable help in this work.
PY - 2000
Y1 - 2000
N2 - We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
AB - We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
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U2 - 10.3109/10428190009065846
DO - 10.3109/10428190009065846
M3 - Article
C2 - 11342327
AN - SCOPUS:0034486840
VL - 39
SP - 441
EP - 446
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 3-4
ER -
