Abstract
We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
| Original language | English |
|---|---|
| Pages (from-to) | 441-446 |
| Number of pages | 6 |
| Journal | Leukemia and Lymphoma |
| Volume | 39 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - 2000 |
All Science Journal Classification (ASJC) codes
- Hematology
- Oncology
- Cancer Research
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Cite this
Maeda, M., Inaba, S., Nomura, A., Tokunaga, Y., Sugio, Y., Itoh, Y., Iino, T., Otsuka, T., Okamura, S., & Niho, Y. (2000). Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells. Leukemia and Lymphoma, 39(3-4), 441-446. https://doi.org/10.3109/10428190009065846