Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system

Toshiro Matsui, Kei Tamaya, Eiji Seki, Katsuhiro Osajima, Kiyoshi Matsumoto, Terukazu Kawasaki

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)

Abstract

1. Intact absorption of the bioactive dipeptide Val-Tyr (VY), with in vivo antihypertensive ability in normotensive human subjects, was investigated. 2. As a result of a single oral administration of VY, the VY absorption curve occurred maximally over the second hour postprandially; a greater than 10-fold higher increment of VY following a dose of 12 mg was observed in the plasma at 2 h compared with the baseline concentration of VY at 0 h (1934 ± 145 vs 159 ± 11 fmol/mL plasma, respectively). 3. Plasma VY levels increased with dose administered (3, 6 and 12 mg), suggesting that exogenous VY could be absorbed intact into the human blood depending on the dose. The elimination half time (t1/2) of VY was estimated to be 3.1 h. The area under the curve for the 12 mg VY dose was 9185 ± 688 fmol·h/mL plasma.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume29
Issue number3
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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